Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner

Background Erythropoietin (Epo), the primary regulator of erythropoiesis, has recently been shown to exert antiinflammatory and antiapoptotic properties in neuronal and myocardial tissue. We herein studied whether Epo pretreatment can reduce cell death and ischemic necrosis in a chronic in vivo mode...

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Veröffentlicht in:	Surgery 2009-04, Vol.145 (4), p.372-383
Hauptverfasser:	Harder, Yves, MD, Amon, Michaela, MD, Schramm, René, MD, PhD, Contaldo, Claudio, MD, Metzkow, Eva, MD, Matzen, Anne, MD, Rücker, Martin, MD, Vollmar, Brigitte, MD, Menger, Michael D., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cell Adhesion - drug effects Endothelial Cells - drug effects Endothelium, Vascular - immunology Erythropoietin - pharmacology Erythropoietin - therapeutic use General aspects Hematocrit Ischemia - drug therapy Ischemia - immunology Leukocytes - drug effects Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Microcirculation - drug effects Necrosis - prevention & control Neovascularization, Physiologic - drug effects Receptors, Erythropoietin - metabolism Surgery Surgical Flaps - blood supply Surgical Flaps - pathology
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