The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

Viral infection activates transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and elicit innate antiviral response. MITA (also known as STING) has recently been identified as an adaptor that links virus-sensing receptors to IRF3 activation. Here, we showed tha...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2009-03, Vol.30 (3), p.397-407
Hauptverfasser:	Zhong, Bo, Zhang, Lu, Lei, Caoqi, Li, Ying, Mao, Ai-Ping, Yang, Yan, Wang, Yan-Yi, Zhang, Xiao-Lian, Shu, Hong-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - metabolism Animals CELLIMMUNO Cells, Cultured Cloning DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Experiments Gene Expression Regulation Gene Knockdown Techniques HeLa Cells Humans Immune system Interferon-beta - genetics Interferon-beta - metabolism Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism Kinases Membrane Proteins - metabolism Mice Mitochondria MOLIMMUNO NF-kappa B - genetics NF-kappa B - metabolism Promoter Regions, Genetic Proteins Signal Transduction Studies Transcription factors Ubiquitin-Protein Ligases Up-Regulation Viral infections Virus Diseases - immunology Viruses - immunology
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