Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was de...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2009-03, Vol.30 (3), p.458-469
Hauptverfasser:	Zhang, Nan, Schröppel, Bernd, Lal, Girdhari, Jakubzick, Claudia, Mao, Xia, Chen, Dan, Yin, Na, Jessberger, Rolf, Ochando, Jordi C., Ding, Yaozhong, Bromberg, Jonathan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity - immunology Cell adhesion & migration Cell Movement - immunology CELLIMMUNO Cells, Cultured Chemokines Dendritic Cells - immunology Dendritic Cells - physiology Fatty acids Immune system Inflammation Islets of Langerhans - cytology Islets of Langerhans - immunology Ligands Lymph Nodes - immunology Lymphocyte Subsets - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy Reverse Transcriptase Polymerase Chain Reaction Rodents Software Studies Survival analysis T cell receptors T-Lymphocytes, Regulatory - immunology Variance analysis
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