Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults
Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determina...
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| creator | Woodside, J.V. McMahon, R. Gallagher, A.M. Cran, G.W. Boreham, C.A. Murray, L.J. Strain, J.J. McNulty, H. Robson, P.J. Brown, K.S. Whitehead, A.S. Savage, M. Young, I.S. |
| description | Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults.
Methods and results: A total of 489 subjects aged 20–25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aorto-iliac segment (
P = 0.18), the aorto-radial segment (
P = 0.39) or the aorto-dorsalis-pedis segment (
P = 0.22). When tHcy was classified into normal ( |
| doi_str_mv | 10.1016/j.atherosclerosis.2004.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67049584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915004003417</els_id><sourcerecordid>67049584</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-fe785b66ea01aa4b06d3b81a88c0be8f82c0d58d3f3586f964ce60ae0dec6a7f3</originalsourceid><addsrcrecordid>eNqNkMFu1DAQhq0KRJfCKyBfyi1hvIkd58ABVdAiVeJSztbEmXS9SuLFdhbl7fFqV1TixGVGI33zz-hj7FZAKUCoT_sS046Cj3Y8VRfLLUBdQlMCiCu2EbppC1Hr-hXbAGxF0QoJ1-xtjHvIYCP0G3YtpKygBb1h5sknHPnOT96uMZGbibvIZ5848p4ShcnNOCfuB44hjy7Th2WMxH_jkfiRRm9dWrmb-eqX-ZnvCMe0Wzn2y5jiO_Z6wEy_v_Qb9vPb16e7h-Lxx_33uy-Pha2FTMVAjZadUoQgEOsOVF91WqDWFjrSg95a6KXuq6GSWg2tqi0pQIKerMJmqG7Yx3PuIfhfC8VkJhctjSPO5JdoVAN1K3Wdwc9n0GZ7MdBgDsFNGFYjwJwMm735x7A5GTbQmGw473-4HFq6ifqX7YvSDNxeAIwWxyHgbHPGX05VUrbtKej-zFHWcnQUTLSOZku9C2ST6b37z5f-ABjdpig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67049584</pqid></control><display><type>article</type><title>Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Woodside, J.V. ; McMahon, R. ; Gallagher, A.M. ; Cran, G.W. ; Boreham, C.A. ; Murray, L.J. ; Strain, J.J. ; McNulty, H. ; Robson, P.J. ; Brown, K.S. ; Whitehead, A.S. ; Savage, M. ; Young, I.S.</creator><creatorcontrib>Woodside, J.V. ; McMahon, R. ; Gallagher, A.M. ; Cran, G.W. ; Boreham, C.A. ; Murray, L.J. ; Strain, J.J. ; McNulty, H. ; Robson, P.J. ; Brown, K.S. ; Whitehead, A.S. ; Savage, M. ; Young, I.S.</creatorcontrib><description>Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults.
Methods and results: A total of 489 subjects aged 20–25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aorto-iliac segment (
P = 0.18), the aorto-radial segment (
P = 0.39) or the aorto-dorsalis-pedis segment (
P = 0.22). When tHcy was classified into normal (<15) and high (≥15
μmol/l), PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac,
P < 0.001; aorto-radial,
P = 0.01; aorto-dorsalis-pedis,
P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments.
Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2004.07.001</identifier><identifier>PMID: 15530908</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adult ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Flow Velocity - physiology ; Blood Pressure ; Cardiology. Vascular system ; Cardiovascular disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Folic Acid - blood ; Homocysteine - blood ; Humans ; Male ; Medical sciences ; Orthopedic surgery ; Pulse ; Pulse wave velocity ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Total homocysteine ; Young adults</subject><ispartof>Atherosclerosis, 2004-12, Vol.177 (2), p.337-344</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-fe785b66ea01aa4b06d3b81a88c0be8f82c0d58d3f3586f964ce60ae0dec6a7f3</citedby><cites>FETCH-LOGICAL-c415t-fe785b66ea01aa4b06d3b81a88c0be8f82c0d58d3f3586f964ce60ae0dec6a7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915004003417$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16355991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15530908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodside, J.V.</creatorcontrib><creatorcontrib>McMahon, R.</creatorcontrib><creatorcontrib>Gallagher, A.M.</creatorcontrib><creatorcontrib>Cran, G.W.</creatorcontrib><creatorcontrib>Boreham, C.A.</creatorcontrib><creatorcontrib>Murray, L.J.</creatorcontrib><creatorcontrib>Strain, J.J.</creatorcontrib><creatorcontrib>McNulty, H.</creatorcontrib><creatorcontrib>Robson, P.J.</creatorcontrib><creatorcontrib>Brown, K.S.</creatorcontrib><creatorcontrib>Whitehead, A.S.</creatorcontrib><creatorcontrib>Savage, M.</creatorcontrib><creatorcontrib>Young, I.S.</creatorcontrib><title>Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults.
Methods and results: A total of 489 subjects aged 20–25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aorto-iliac segment (
P = 0.18), the aorto-radial segment (
P = 0.39) or the aorto-dorsalis-pedis segment (
P = 0.22). When tHcy was classified into normal (<15) and high (≥15
μmol/l), PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac,
P < 0.001; aorto-radial,
P = 0.01; aorto-dorsalis-pedis,
P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments.
Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population.</description><subject>Adult</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Orthopedic surgery</subject><subject>Pulse</subject><subject>Pulse wave velocity</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Total homocysteine</subject><subject>Young adults</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhq0KRJfCKyBfyi1hvIkd58ABVdAiVeJSztbEmXS9SuLFdhbl7fFqV1TixGVGI33zz-hj7FZAKUCoT_sS046Cj3Y8VRfLLUBdQlMCiCu2EbppC1Hr-hXbAGxF0QoJ1-xtjHvIYCP0G3YtpKygBb1h5sknHPnOT96uMZGbibvIZ5848p4ShcnNOCfuB44hjy7Th2WMxH_jkfiRRm9dWrmb-eqX-ZnvCMe0Wzn2y5jiO_Z6wEy_v_Qb9vPb16e7h-Lxx_33uy-Pha2FTMVAjZadUoQgEOsOVF91WqDWFjrSg95a6KXuq6GSWg2tqi0pQIKerMJmqG7Yx3PuIfhfC8VkJhctjSPO5JdoVAN1K3Wdwc9n0GZ7MdBgDsFNGFYjwJwMm735x7A5GTbQmGw473-4HFq6ifqX7YvSDNxeAIwWxyHgbHPGX05VUrbtKej-zFHWcnQUTLSOZku9C2ST6b37z5f-ABjdpig</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Woodside, J.V.</creator><creator>McMahon, R.</creator><creator>Gallagher, A.M.</creator><creator>Cran, G.W.</creator><creator>Boreham, C.A.</creator><creator>Murray, L.J.</creator><creator>Strain, J.J.</creator><creator>McNulty, H.</creator><creator>Robson, P.J.</creator><creator>Brown, K.S.</creator><creator>Whitehead, A.S.</creator><creator>Savage, M.</creator><creator>Young, I.S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults</title><author>Woodside, J.V. ; McMahon, R. ; Gallagher, A.M. ; Cran, G.W. ; Boreham, C.A. ; Murray, L.J. ; Strain, J.J. ; McNulty, H. ; Robson, P.J. ; Brown, K.S. ; Whitehead, A.S. ; Savage, M. ; Young, I.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-fe785b66ea01aa4b06d3b81a88c0be8f82c0d58d3f3586f964ce60ae0dec6a7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Orthopedic surgery</topic><topic>Pulse</topic><topic>Pulse wave velocity</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Total homocysteine</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodside, J.V.</creatorcontrib><creatorcontrib>McMahon, R.</creatorcontrib><creatorcontrib>Gallagher, A.M.</creatorcontrib><creatorcontrib>Cran, G.W.</creatorcontrib><creatorcontrib>Boreham, C.A.</creatorcontrib><creatorcontrib>Murray, L.J.</creatorcontrib><creatorcontrib>Strain, J.J.</creatorcontrib><creatorcontrib>McNulty, H.</creatorcontrib><creatorcontrib>Robson, P.J.</creatorcontrib><creatorcontrib>Brown, K.S.</creatorcontrib><creatorcontrib>Whitehead, A.S.</creatorcontrib><creatorcontrib>Savage, M.</creatorcontrib><creatorcontrib>Young, I.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woodside, J.V.</au><au>McMahon, R.</au><au>Gallagher, A.M.</au><au>Cran, G.W.</au><au>Boreham, C.A.</au><au>Murray, L.J.</au><au>Strain, J.J.</au><au>McNulty, H.</au><au>Robson, P.J.</au><au>Brown, K.S.</au><au>Whitehead, A.S.</au><au>Savage, M.</au><au>Young, I.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>177</volume><issue>2</issue><spage>337</spage><epage>344</epage><pages>337-344</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults.
Methods and results: A total of 489 subjects aged 20–25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aorto-iliac segment (
P = 0.18), the aorto-radial segment (
P = 0.39) or the aorto-dorsalis-pedis segment (
P = 0.22). When tHcy was classified into normal (<15) and high (≥15
μmol/l), PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac,
P < 0.001; aorto-radial,
P = 0.01; aorto-dorsalis-pedis,
P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments.
Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15530908</pmid><doi>10.1016/j.atherosclerosis.2004.07.001</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Flow Velocity - physiology Blood Pressure Cardiology. Vascular system Cardiovascular disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Folic Acid - blood Homocysteine - blood Humans Male Medical sciences Orthopedic surgery Pulse Pulse wave velocity Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Total homocysteine Young adults |
| title | Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults |
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