Synthetic medicinal chemistry of selected antimalarial natural products
A variety of natural products have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malar...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry 2009-03, Vol.17 (6), p.2236-2275 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2275 |
|---|---|
| container_issue | 6 |
| container_start_page | 2236 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 17 |
| creator | Kumar, Vipan Mahajan, Aman Chibale, Kelly |
| description | A variety of natural products have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials.
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs. |
| doi_str_mv | 10.1016/j.bmc.2008.10.072 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67048439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0968089608010341</els_id><sourcerecordid>67048439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-bf07d6f5850c59c78eeccc347a984b83cf7558022258ff58ff1b74b5bd01e4183</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo7rr6A7xIT95aJ23apHiSxS9Y8KCeQzudslm67Zqkwv57U3bBmx7CkOGZN5mHsWsOCQde3G2SeotJCqDCPQGZnrA5F4WIs6zkp2wOZaFiUGUxYxfObQAgFSU_ZzNe8lwqlc3Z8_u-92vyBqMtNQZNX3URrmlrnLf7aGgjRx2hpyaqem-2VVdZE5C-8qMNdWeHZkTvLtlZW3WOro51wT6fHj-WL_Hq7fl1-bCKUQjl47oF2RRtrnLAvESpiBAxE7IqlahVhq3McwVpmuaqbafDaynqvG6Ak-AqW7DbQ254-Gsk53X4KVLXVT0No9OFBKFEVv4LpiAkFGoC-QFEOzhnqdU7G_a0e81BT5r1RgfNetI8tYLmMHNzDB_roO134ug1APcHgIKLb0NWOzTUY1Bsg03dDOaP-B_P-Y39</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20470689</pqid></control><display><type>article</type><title>Synthetic medicinal chemistry of selected antimalarial natural products</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kumar, Vipan ; Mahajan, Aman ; Chibale, Kelly</creator><creatorcontrib>Kumar, Vipan ; Mahajan, Aman ; Chibale, Kelly</creatorcontrib><description>A variety of natural products have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials.
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2008.10.072</identifier><identifier>PMID: 19157883</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alkaloids ; Animals ; Antimalarial agents ; Antimalarials - chemistry ; Antimalarials - pharmacology ; Artemisinin ; Biological Products - chemistry ; Biological Products - pharmacology ; Chemistry, Pharmaceutical ; Humans ; Plasmodium falciparum ; Quassinoids</subject><ispartof>Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2236-2275</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-bf07d6f5850c59c78eeccc347a984b83cf7558022258ff58ff1b74b5bd01e4183</citedby><cites>FETCH-LOGICAL-c448t-bf07d6f5850c59c78eeccc347a984b83cf7558022258ff58ff1b74b5bd01e4183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089608010341$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19157883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Vipan</creatorcontrib><creatorcontrib>Mahajan, Aman</creatorcontrib><creatorcontrib>Chibale, Kelly</creatorcontrib><title>Synthetic medicinal chemistry of selected antimalarial natural products</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>A variety of natural products have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials.
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs.</description><subject>Alkaloids</subject><subject>Animals</subject><subject>Antimalarial agents</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - pharmacology</subject><subject>Artemisinin</subject><subject>Biological Products - chemistry</subject><subject>Biological Products - pharmacology</subject><subject>Chemistry, Pharmaceutical</subject><subject>Humans</subject><subject>Plasmodium falciparum</subject><subject>Quassinoids</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6A7xIT95aJ23apHiSxS9Y8KCeQzudslm67Zqkwv57U3bBmx7CkOGZN5mHsWsOCQde3G2SeotJCqDCPQGZnrA5F4WIs6zkp2wOZaFiUGUxYxfObQAgFSU_ZzNe8lwqlc3Z8_u-92vyBqMtNQZNX3URrmlrnLf7aGgjRx2hpyaqem-2VVdZE5C-8qMNdWeHZkTvLtlZW3WOro51wT6fHj-WL_Hq7fl1-bCKUQjl47oF2RRtrnLAvESpiBAxE7IqlahVhq3McwVpmuaqbafDaynqvG6Ak-AqW7DbQ254-Gsk53X4KVLXVT0No9OFBKFEVv4LpiAkFGoC-QFEOzhnqdU7G_a0e81BT5r1RgfNetI8tYLmMHNzDB_roO134ug1APcHgIKLb0NWOzTUY1Bsg03dDOaP-B_P-Y39</recordid><startdate>20090315</startdate><enddate>20090315</enddate><creator>Kumar, Vipan</creator><creator>Mahajan, Aman</creator><creator>Chibale, Kelly</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090315</creationdate><title>Synthetic medicinal chemistry of selected antimalarial natural products</title><author>Kumar, Vipan ; Mahajan, Aman ; Chibale, Kelly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-bf07d6f5850c59c78eeccc347a984b83cf7558022258ff58ff1b74b5bd01e4183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alkaloids</topic><topic>Animals</topic><topic>Antimalarial agents</topic><topic>Antimalarials - chemistry</topic><topic>Antimalarials - pharmacology</topic><topic>Artemisinin</topic><topic>Biological Products - chemistry</topic><topic>Biological Products - pharmacology</topic><topic>Chemistry, Pharmaceutical</topic><topic>Humans</topic><topic>Plasmodium falciparum</topic><topic>Quassinoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Vipan</creatorcontrib><creatorcontrib>Mahajan, Aman</creatorcontrib><creatorcontrib>Chibale, Kelly</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Vipan</au><au>Mahajan, Aman</au><au>Chibale, Kelly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetic medicinal chemistry of selected antimalarial natural products</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2009-03-15</date><risdate>2009</risdate><volume>17</volume><issue>6</issue><spage>2236</spage><epage>2275</epage><pages>2236-2275</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>A variety of natural products have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials.
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19157883</pmid><doi>10.1016/j.bmc.2008.10.072</doi><tpages>40</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2236-2275 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67048439 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alkaloids Animals Antimalarial agents Antimalarials - chemistry Antimalarials - pharmacology Artemisinin Biological Products - chemistry Biological Products - pharmacology Chemistry, Pharmaceutical Humans Plasmodium falciparum Quassinoids |
| title | Synthetic medicinal chemistry of selected antimalarial natural products |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T17%3A02%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthetic%20medicinal%20chemistry%20of%20selected%20antimalarial%20natural%20products&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=Kumar,%20Vipan&rft.date=2009-03-15&rft.volume=17&rft.issue=6&rft.spage=2236&rft.epage=2275&rft.pages=2236-2275&rft.issn=0968-0896&rft.eissn=1464-3391&rft_id=info:doi/10.1016/j.bmc.2008.10.072&rft_dat=%3Cproquest_cross%3E67048439%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20470689&rft_id=info:pmid/19157883&rft_els_id=S0968089608010341&rfr_iscdi=true |