Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection
Chronic Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mou...
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| Veröffentlicht in: | Atherosclerosis 2004-12, Vol.177 (2), p.321-328 |
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| creator | Erkkilä, L. Laitinen, K. Haasio, K. Tiirola, T. Jauhiainen, M. Lehr, H.A. Aalto-Setälä, K. Saikku, P. Leinonen, M. |
| description | Chronic
Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of
C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice. In addition, pulmonary infection was investigated. C57BL/6JBom mice were given one to three
C. pneumoniae inoculations and fed either a regular diet or a diet enriched with 0.2% cholesterol. Autoantibody responses against mouse Hsp60 developed in both diet groups when the mice were infected with
C. pneumoniae and in uninfected mice fed a cholesterol-enriched diet.
C. pneumoniae infections increased subendothelial foam cell accumulation in mice on a 0.2% cholesterol-enriched diet (
p = 0.022), without apparent hypercholesterolemia. These in vivo data suggest that autoantibodies against mouse Hsp60 develop as a consequence of cholesterol feeding and repeated
C. pneumoniae infections. Further, infectious burden increased early lipid lesions in C57BL/6JBom mice fed a cholesterol-enriched diet. |
| doi_str_mv | 10.1016/j.atherosclerosis.2004.08.021 |
| format | Article |
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Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of
C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice. In addition, pulmonary infection was investigated. C57BL/6JBom mice were given one to three
C. pneumoniae inoculations and fed either a regular diet or a diet enriched with 0.2% cholesterol. Autoantibody responses against mouse Hsp60 developed in both diet groups when the mice were infected with
C. pneumoniae and in uninfected mice fed a cholesterol-enriched diet.
C. pneumoniae infections increased subendothelial foam cell accumulation in mice on a 0.2% cholesterol-enriched diet (
p = 0.022), without apparent hypercholesterolemia. These in vivo data suggest that autoantibodies against mouse Hsp60 develop as a consequence of cholesterol feeding and repeated
C. pneumoniae infections. Further, infectious burden increased early lipid lesions in C57BL/6JBom mice fed a cholesterol-enriched diet.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2004.08.021</identifier><identifier>PMID: 15530906</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Animals ; Aortic Valve - pathology ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Autoimmunity ; Biological and medical sciences ; Blood and lymphatic vessels ; C57BL/6JBom mouse ; Cardiology. Vascular system ; Chaperonin 60 - immunology ; Chlamydia Infections - immunology ; Chlamydia Infections - pathology ; Chlamydia pneumoniae ; Chlamydophila pneumoniae ; Cholesterol diet ; Cholesterol, Dietary ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; General and cellular metabolism. Vitamins ; Heat shock protein 60 ; Lung Diseases - immunology ; Medical sciences ; Mice ; Pharmacology. Drug treatments</subject><ispartof>Atherosclerosis, 2004-12, Vol.177 (2), p.321-328</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-b91c5f648fcd9992c0c81a361dd575280a040880e1801297bf20449ce10626663</citedby><cites>FETCH-LOGICAL-c415t-b91c5f648fcd9992c0c81a361dd575280a040880e1801297bf20449ce10626663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915004004071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16355989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15530906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erkkilä, L.</creatorcontrib><creatorcontrib>Laitinen, K.</creatorcontrib><creatorcontrib>Haasio, K.</creatorcontrib><creatorcontrib>Tiirola, T.</creatorcontrib><creatorcontrib>Jauhiainen, M.</creatorcontrib><creatorcontrib>Lehr, H.A.</creatorcontrib><creatorcontrib>Aalto-Setälä, K.</creatorcontrib><creatorcontrib>Saikku, P.</creatorcontrib><creatorcontrib>Leinonen, M.</creatorcontrib><title>Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Chronic
Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of
C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice. In addition, pulmonary infection was investigated. C57BL/6JBom mice were given one to three
C. pneumoniae inoculations and fed either a regular diet or a diet enriched with 0.2% cholesterol. Autoantibody responses against mouse Hsp60 developed in both diet groups when the mice were infected with
C. pneumoniae and in uninfected mice fed a cholesterol-enriched diet.
C. pneumoniae infections increased subendothelial foam cell accumulation in mice on a 0.2% cholesterol-enriched diet (
p = 0.022), without apparent hypercholesterolemia. These in vivo data suggest that autoantibodies against mouse Hsp60 develop as a consequence of cholesterol feeding and repeated
C. pneumoniae infections. Further, infectious burden increased early lipid lesions in C57BL/6JBom mice fed a cholesterol-enriched diet.</description><subject>Animals</subject><subject>Aortic Valve - pathology</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>C57BL/6JBom mouse</subject><subject>Cardiology. Vascular system</subject><subject>Chaperonin 60 - immunology</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia Infections - pathology</subject><subject>Chlamydia pneumoniae</subject><subject>Chlamydophila pneumoniae</subject><subject>Cholesterol diet</subject><subject>Cholesterol, Dietary</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heat shock protein 60</subject><subject>Lung Diseases - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGPEyEYxYnRuHX1XzBc1tt0P6YDAwcPbqO7miZe9EwofGOpDFSYMendP1yaNmuyJy8QyO89Hu8j5IbBkgETt_ulmXaYU7HhtPqybAG6JcgltOwZWTDZq4Z1sntOFlCvGsU4XJFXpeyhgj2TL8kV43wFCsSC_HlAM9GyS_YnPeQ0oY9UADXzlPw4ztFPR2qio2hyONLgD97RgMWnWGhF7S7V01SThGZAR9e8v9vcii93aaSjt0jdnH38Qde7YMaj84YeIs5jit5g1Q9op2r1mrwYTCj45rJfk--fPn5bPzSbr_ef1x82je0Yn5qtYpYPopODdUqp1oKVzKwEc473vJVgoAMpAZkE1qp-O7TQdcoiA9EKIVbX5N3Zt_7011xz69EXiyGYiGkuWvS1IMlkBd-fQVsrLhkHfch-NPmoGejTGPRePxmDPo1Bg9S186p_e3lo3o7o_qkvvVfg5gKYYk0Ysom2ejxyYsW5kqpy92cOay2_PWZdrMdo0flcu9Mu-f-M9BdVE7Av</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Erkkilä, L.</creator><creator>Laitinen, K.</creator><creator>Haasio, K.</creator><creator>Tiirola, T.</creator><creator>Jauhiainen, M.</creator><creator>Lehr, H.A.</creator><creator>Aalto-Setälä, K.</creator><creator>Saikku, P.</creator><creator>Leinonen, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection</title><author>Erkkilä, L. ; Laitinen, K. ; Haasio, K. ; Tiirola, T. ; Jauhiainen, M. ; Lehr, H.A. ; Aalto-Setälä, K. ; Saikku, P. ; Leinonen, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-b91c5f648fcd9992c0c81a361dd575280a040880e1801297bf20449ce10626663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Aortic Valve - pathology</topic><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>C57BL/6JBom mouse</topic><topic>Cardiology. Vascular system</topic><topic>Chaperonin 60 - immunology</topic><topic>Chlamydia Infections - immunology</topic><topic>Chlamydia Infections - pathology</topic><topic>Chlamydia pneumoniae</topic><topic>Chlamydophila pneumoniae</topic><topic>Cholesterol diet</topic><topic>Cholesterol, Dietary</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heat shock protein 60</topic><topic>Lung Diseases - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erkkilä, L.</creatorcontrib><creatorcontrib>Laitinen, K.</creatorcontrib><creatorcontrib>Haasio, K.</creatorcontrib><creatorcontrib>Tiirola, T.</creatorcontrib><creatorcontrib>Jauhiainen, M.</creatorcontrib><creatorcontrib>Lehr, H.A.</creatorcontrib><creatorcontrib>Aalto-Setälä, K.</creatorcontrib><creatorcontrib>Saikku, P.</creatorcontrib><creatorcontrib>Leinonen, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erkkilä, L.</au><au>Laitinen, K.</au><au>Haasio, K.</au><au>Tiirola, T.</au><au>Jauhiainen, M.</au><au>Lehr, H.A.</au><au>Aalto-Setälä, K.</au><au>Saikku, P.</au><au>Leinonen, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>177</volume><issue>2</issue><spage>321</spage><epage>328</epage><pages>321-328</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Chronic
Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of
C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice. In addition, pulmonary infection was investigated. C57BL/6JBom mice were given one to three
C. pneumoniae inoculations and fed either a regular diet or a diet enriched with 0.2% cholesterol. Autoantibody responses against mouse Hsp60 developed in both diet groups when the mice were infected with
C. pneumoniae and in uninfected mice fed a cholesterol-enriched diet.
C. pneumoniae infections increased subendothelial foam cell accumulation in mice on a 0.2% cholesterol-enriched diet (
p = 0.022), without apparent hypercholesterolemia. These in vivo data suggest that autoantibodies against mouse Hsp60 develop as a consequence of cholesterol feeding and repeated
C. pneumoniae infections. Further, infectious burden increased early lipid lesions in C57BL/6JBom mice fed a cholesterol-enriched diet.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15530906</pmid><doi>10.1016/j.atherosclerosis.2004.08.021</doi><tpages>8</tpages></addata></record> |
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| ispartof | Atherosclerosis, 2004-12, Vol.177 (2), p.321-328 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Aortic Valve - pathology Associated diseases and complications Atherosclerosis (general aspects, experimental research) Autoimmunity Biological and medical sciences Blood and lymphatic vessels C57BL/6JBom mouse Cardiology. Vascular system Chaperonin 60 - immunology Chlamydia Infections - immunology Chlamydia Infections - pathology Chlamydia pneumoniae Chlamydophila pneumoniae Cholesterol diet Cholesterol, Dietary Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies General and cellular metabolism. Vitamins Heat shock protein 60 Lung Diseases - immunology Medical sciences Mice Pharmacology. Drug treatments |
| title | Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection |
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