Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells
Characteristics for the up-regulated response in the concentration of intracellular calcium ion ([Ca 2+ ] i ) and in the sodium ion (Na + ) current by serotonin (5-HT) were investigated in differentiated neuroblastoma × glioma hybrid NG108-15 (NG) cells. The results for the changes in [Ca 2+ ] i by...
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| Veröffentlicht in: | Neurochemical research 2009-05, Vol.34 (5), p.1011-1019 |
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| creator | Imanishi, Takashi Matsushima, Kayoko Kawaguchi, Akinori Asano, Hajime Funakami, Yoshinori Wada, Tetsuyuki Masuko, Takashi Yoshida, Shigeru Ichida, Seiji |
| description | Characteristics for the up-regulated response in the concentration of intracellular calcium ion ([Ca
2+
]
i
) and in the sodium ion (Na
+
) current by serotonin (5-HT) were investigated in differentiated neuroblastoma × glioma hybrid NG108-15 (NG) cells. The results for the changes in [Ca
2+
]
i
by 5-HT were as follows, (1) The 5-HT-induced Ca
2+
response was inhibited by 3 × 10
−9
M tropisetron (a 5-HT
3
receptor blocker), but not by other types of 5-HT receptor blockers; (2) The 5-HT-induced Ca
2+
response was mainly inhibited by calciseptine (a L-type Ca
2+
blocker), but not by other types of Ca
2+
channel blockers or 10
−7
M TTX (a voltage-sensitive Na
+
channel blocker); (3) When the extracellular Na
+
was removed by exchange with choline chloride or
N
-methyl-
d
-glucamine, the 5-HT-induced Ca
2+
response was extremely inhibited. The results for the 5-HT-induced Na
+
current by the whole cell patch-clamp technique were as follows, (1) The 5-HT-induced Na
+
current in differentiated cells was significantly larger than that in undifferentiated cells; (2) The ED
50
value for 5-HT-induced Na
+
current in undifferentiated and differentiated cells was almost the same, about 4 × 10
−6
M each other; (3) The 5-HT-induced Na
+
current was completely blocked by 3 × 10
−9
M tropisetron, but not by other 5-HT receptor antagonists and 10
−7
M TTX. These results suggested that 5-HT-induced Ca
2+
response in differentiated NG cells was mainly due to L-type voltage-gated Ca
2+
channels allowing extracellular Na
+
to enter via 5-HT
3
receptors, but not through voltage-gated Na
+
channels. |
| doi_str_mv | 10.1007/s11064-008-9839-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67047697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67047697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-57e06e8d3030369214ecc22945242ab1472cbfe82f25004d94e168cfc120c6803</originalsourceid><addsrcrecordid>eNqFkUFrGzEQhUVpaNw0PyCXsPTQ2zajWa1WewyumwZCAklzFrI8Sja1JUdal-Tfd4wNgUIpOkjofe9pxBPiRMJXCdCdFSlBqxrA1L1p-vrlnZjItmtq3UPzXkygYbWRPRyKj6U8AbAL5QdxyFcGjWkn4mH66LLzI-WhjIMvVUi5msVHFz0tqlsq6xQLVSlUd5TTmOIQ69nv9IvFyxSrb6_Rrba2gc9DCJQpjoMbWb6-kDyXbKspLZflkzgIblnoeL8fifvvs5_TH_XVzcXl9Pyq9krrsW47Ak1m0QAv3aNU5D1ir1pU6OZSdejngQwGbAHUolcktfHBSwSvDTRH4ssud53T84bKaFdD8TyBi5Q2xeoOVKf77r8gQmuwM8jg57_Ap7TJkT9hEaXhHlAxJHeQz6mUTMGu87By-dVKsNuu7K4ry13ZbVf2hT2n--DNfEWLN8e-HAZwBxSW4gPlt5f_nfoHdLSdFg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221800724</pqid></control><display><type>article</type><title>Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Imanishi, Takashi ; Matsushima, Kayoko ; Kawaguchi, Akinori ; Asano, Hajime ; Funakami, Yoshinori ; Wada, Tetsuyuki ; Masuko, Takashi ; Yoshida, Shigeru ; Ichida, Seiji</creator><creatorcontrib>Imanishi, Takashi ; Matsushima, Kayoko ; Kawaguchi, Akinori ; Asano, Hajime ; Funakami, Yoshinori ; Wada, Tetsuyuki ; Masuko, Takashi ; Yoshida, Shigeru ; Ichida, Seiji</creatorcontrib><description>Characteristics for the up-regulated response in the concentration of intracellular calcium ion ([Ca
2+
]
i
) and in the sodium ion (Na
+
) current by serotonin (5-HT) were investigated in differentiated neuroblastoma × glioma hybrid NG108-15 (NG) cells. The results for the changes in [Ca
2+
]
i
by 5-HT were as follows, (1) The 5-HT-induced Ca
2+
response was inhibited by 3 × 10
−9
M tropisetron (a 5-HT
3
receptor blocker), but not by other types of 5-HT receptor blockers; (2) The 5-HT-induced Ca
2+
response was mainly inhibited by calciseptine (a L-type Ca
2+
blocker), but not by other types of Ca
2+
channel blockers or 10
−7
M TTX (a voltage-sensitive Na
+
channel blocker); (3) When the extracellular Na
+
was removed by exchange with choline chloride or
N
-methyl-
d
-glucamine, the 5-HT-induced Ca
2+
response was extremely inhibited. The results for the 5-HT-induced Na
+
current by the whole cell patch-clamp technique were as follows, (1) The 5-HT-induced Na
+
current in differentiated cells was significantly larger than that in undifferentiated cells; (2) The ED
50
value for 5-HT-induced Na
+
current in undifferentiated and differentiated cells was almost the same, about 4 × 10
−6
M each other; (3) The 5-HT-induced Na
+
current was completely blocked by 3 × 10
−9
M tropisetron, but not by other 5-HT receptor antagonists and 10
−7
M TTX. These results suggested that 5-HT-induced Ca
2+
response in differentiated NG cells was mainly due to L-type voltage-gated Ca
2+
channels allowing extracellular Na
+
to enter via 5-HT
3
receptors, but not through voltage-gated Na
+
channels.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-008-9839-x</identifier><identifier>PMID: 19082885</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Calcium - physiology ; Calcium Channel Blockers - pharmacology ; Calcium Channels, L-Type - physiology ; Cations, Divalent ; Cations, Monovalent ; Cell Biology ; Cell Differentiation ; Cell Line, Tumor ; Hybrid Cells ; Ion Channel Gating ; Mice ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Patch-Clamp Techniques ; Rats ; Receptors, Serotonin, 5-HT3 - physiology ; Serotonin - physiology ; Serotonin Antagonists - pharmacology ; Sodium - physiology ; Sodium Channels - physiology</subject><ispartof>Neurochemical research, 2009-05, Vol.34 (5), p.1011-1019</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>Springer Science+Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-57e06e8d3030369214ecc22945242ab1472cbfe82f25004d94e168cfc120c6803</citedby><cites>FETCH-LOGICAL-c466t-57e06e8d3030369214ecc22945242ab1472cbfe82f25004d94e168cfc120c6803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-008-9839-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-008-9839-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19082885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imanishi, Takashi</creatorcontrib><creatorcontrib>Matsushima, Kayoko</creatorcontrib><creatorcontrib>Kawaguchi, Akinori</creatorcontrib><creatorcontrib>Asano, Hajime</creatorcontrib><creatorcontrib>Funakami, Yoshinori</creatorcontrib><creatorcontrib>Wada, Tetsuyuki</creatorcontrib><creatorcontrib>Masuko, Takashi</creatorcontrib><creatorcontrib>Yoshida, Shigeru</creatorcontrib><creatorcontrib>Ichida, Seiji</creatorcontrib><title>Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Characteristics for the up-regulated response in the concentration of intracellular calcium ion ([Ca
2+
]
i
) and in the sodium ion (Na
+
) current by serotonin (5-HT) were investigated in differentiated neuroblastoma × glioma hybrid NG108-15 (NG) cells. The results for the changes in [Ca
2+
]
i
by 5-HT were as follows, (1) The 5-HT-induced Ca
2+
response was inhibited by 3 × 10
−9
M tropisetron (a 5-HT
3
receptor blocker), but not by other types of 5-HT receptor blockers; (2) The 5-HT-induced Ca
2+
response was mainly inhibited by calciseptine (a L-type Ca
2+
blocker), but not by other types of Ca
2+
channel blockers or 10
−7
M TTX (a voltage-sensitive Na
+
channel blocker); (3) When the extracellular Na
+
was removed by exchange with choline chloride or
N
-methyl-
d
-glucamine, the 5-HT-induced Ca
2+
response was extremely inhibited. The results for the 5-HT-induced Na
+
current by the whole cell patch-clamp technique were as follows, (1) The 5-HT-induced Na
+
current in differentiated cells was significantly larger than that in undifferentiated cells; (2) The ED
50
value for 5-HT-induced Na
+
current in undifferentiated and differentiated cells was almost the same, about 4 × 10
−6
M each other; (3) The 5-HT-induced Na
+
current was completely blocked by 3 × 10
−9
M tropisetron, but not by other 5-HT receptor antagonists and 10
−7
M TTX. These results suggested that 5-HT-induced Ca
2+
response in differentiated NG cells was mainly due to L-type voltage-gated Ca
2+
channels allowing extracellular Na
+
to enter via 5-HT
3
receptors, but not through voltage-gated Na
+
channels.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium - physiology</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channels, L-Type - physiology</subject><subject>Cations, Divalent</subject><subject>Cations, Monovalent</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell Line, Tumor</subject><subject>Hybrid Cells</subject><subject>Ion Channel Gating</subject><subject>Mice</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Patch-Clamp Techniques</subject><subject>Rats</subject><subject>Receptors, Serotonin, 5-HT3 - physiology</subject><subject>Serotonin - physiology</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Sodium - physiology</subject><subject>Sodium Channels - physiology</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUFrGzEQhUVpaNw0PyCXsPTQ2zajWa1WewyumwZCAklzFrI8Sja1JUdal-Tfd4wNgUIpOkjofe9pxBPiRMJXCdCdFSlBqxrA1L1p-vrlnZjItmtq3UPzXkygYbWRPRyKj6U8AbAL5QdxyFcGjWkn4mH66LLzI-WhjIMvVUi5msVHFz0tqlsq6xQLVSlUd5TTmOIQ69nv9IvFyxSrb6_Rrba2gc9DCJQpjoMbWb6-kDyXbKspLZflkzgIblnoeL8fifvvs5_TH_XVzcXl9Pyq9krrsW47Ak1m0QAv3aNU5D1ir1pU6OZSdejngQwGbAHUolcktfHBSwSvDTRH4ssud53T84bKaFdD8TyBi5Q2xeoOVKf77r8gQmuwM8jg57_Ap7TJkT9hEaXhHlAxJHeQz6mUTMGu87By-dVKsNuu7K4ry13ZbVf2hT2n--DNfEWLN8e-HAZwBxSW4gPlt5f_nfoHdLSdFg</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Imanishi, Takashi</creator><creator>Matsushima, Kayoko</creator><creator>Kawaguchi, Akinori</creator><creator>Asano, Hajime</creator><creator>Funakami, Yoshinori</creator><creator>Wada, Tetsuyuki</creator><creator>Masuko, Takashi</creator><creator>Yoshida, Shigeru</creator><creator>Ichida, Seiji</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells</title><author>Imanishi, Takashi ; Matsushima, Kayoko ; Kawaguchi, Akinori ; Asano, Hajime ; Funakami, Yoshinori ; Wada, Tetsuyuki ; Masuko, Takashi ; Yoshida, Shigeru ; Ichida, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-57e06e8d3030369214ecc22945242ab1472cbfe82f25004d94e168cfc120c6803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium - physiology</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channels, L-Type - physiology</topic><topic>Cations, Divalent</topic><topic>Cations, Monovalent</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Cell Line, Tumor</topic><topic>Hybrid Cells</topic><topic>Ion Channel Gating</topic><topic>Mice</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Patch-Clamp Techniques</topic><topic>Rats</topic><topic>Receptors, Serotonin, 5-HT3 - physiology</topic><topic>Serotonin - physiology</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Sodium - physiology</topic><topic>Sodium Channels - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imanishi, Takashi</creatorcontrib><creatorcontrib>Matsushima, Kayoko</creatorcontrib><creatorcontrib>Kawaguchi, Akinori</creatorcontrib><creatorcontrib>Asano, Hajime</creatorcontrib><creatorcontrib>Funakami, Yoshinori</creatorcontrib><creatorcontrib>Wada, Tetsuyuki</creatorcontrib><creatorcontrib>Masuko, Takashi</creatorcontrib><creatorcontrib>Yoshida, Shigeru</creatorcontrib><creatorcontrib>Ichida, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imanishi, Takashi</au><au>Matsushima, Kayoko</au><au>Kawaguchi, Akinori</au><au>Asano, Hajime</au><au>Funakami, Yoshinori</au><au>Wada, Tetsuyuki</au><au>Masuko, Takashi</au><au>Yoshida, Shigeru</au><au>Ichida, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>34</volume><issue>5</issue><spage>1011</spage><epage>1019</epage><pages>1011-1019</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Characteristics for the up-regulated response in the concentration of intracellular calcium ion ([Ca
2+
]
i
) and in the sodium ion (Na
+
) current by serotonin (5-HT) were investigated in differentiated neuroblastoma × glioma hybrid NG108-15 (NG) cells. The results for the changes in [Ca
2+
]
i
by 5-HT were as follows, (1) The 5-HT-induced Ca
2+
response was inhibited by 3 × 10
−9
M tropisetron (a 5-HT
3
receptor blocker), but not by other types of 5-HT receptor blockers; (2) The 5-HT-induced Ca
2+
response was mainly inhibited by calciseptine (a L-type Ca
2+
blocker), but not by other types of Ca
2+
channel blockers or 10
−7
M TTX (a voltage-sensitive Na
+
channel blocker); (3) When the extracellular Na
+
was removed by exchange with choline chloride or
N
-methyl-
d
-glucamine, the 5-HT-induced Ca
2+
response was extremely inhibited. The results for the 5-HT-induced Na
+
current by the whole cell patch-clamp technique were as follows, (1) The 5-HT-induced Na
+
current in differentiated cells was significantly larger than that in undifferentiated cells; (2) The ED
50
value for 5-HT-induced Na
+
current in undifferentiated and differentiated cells was almost the same, about 4 × 10
−6
M each other; (3) The 5-HT-induced Na
+
current was completely blocked by 3 × 10
−9
M tropisetron, but not by other 5-HT receptor antagonists and 10
−7
M TTX. These results suggested that 5-HT-induced Ca
2+
response in differentiated NG cells was mainly due to L-type voltage-gated Ca
2+
channels allowing extracellular Na
+
to enter via 5-HT
3
receptors, but not through voltage-gated Na
+
channels.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19082885</pmid><doi>10.1007/s11064-008-9839-x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neurochemical research, 2009-05, Vol.34 (5), p.1011-1019 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67047697 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Calcium - physiology Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - physiology Cations, Divalent Cations, Monovalent Cell Biology Cell Differentiation Cell Line, Tumor Hybrid Cells Ion Channel Gating Mice Neurochemistry Neurology Neurosciences Original Paper Patch-Clamp Techniques Rats Receptors, Serotonin, 5-HT3 - physiology Serotonin - physiology Serotonin Antagonists - pharmacology Sodium - physiology Sodium Channels - physiology |
| title | Characteristics for Enhanced Response of Serotonin-Evoked Ion Dynamics in Differentiated NG108-15 Cells |
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