Genetic Influence on Inflammation Variables in the Elderly
BACKGROUND—Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic facto...
Gespeichert in:
| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-11, Vol.24 (11), p.2168-2173 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2173 |
|---|---|
| container_issue | 11 |
| container_start_page | 2168 |
| container_title | Arteriosclerosis, thrombosis, and vascular biology |
| container_volume | 24 |
| creator | de Maat, Moniek P.M Bladbjerg, Else Marie Hjelmborg, Jacob von Bornemann Bathum, Lise Jespersen, Jørgen Christensen, Kaare |
| description | BACKGROUND—Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables and of the acute phase regulating cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) at older ages.
METHODS AND RESULTS—The heritability of CRP, fibrinogen, sICAM-1, IL-6, and TNF-α was determined in a twin study consisting of 129 monozygotic twin pairs and 153 dizygotic same-sex twins aged 73 to 94 years who participated in the Longitudinal Study of Aging of Danish Twins. Furthermore, we determined the influence of selected genetic polymorphisms on the plasma level variations. Genetic factors accounted for 20% to 55% of the variation in plasma levels of the inflammation variables. The highest heritability was found for sICAM-1. The genetic polymorphisms we studied explained only a small, insignificant part of the heritability.
CONCLUSIONS—This study in elderly twins provides evidence for a substantial genetic component of inflammatory cardiovascular risk factors among the elderly. |
| doi_str_mv | 10.1161/01.ATV.0000143856.01669.e7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67046807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>849744681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5702-ae9f2797aa92880b81c7ec4a82b6a4524f649ed341d6718de7455c9635c0f6b63</originalsourceid><addsrcrecordid>eNpdkEtr3TAQhUVpadK0f6GYQLuzq9FjZGcXQpoEAtmk2QpZHnOdynYq2YT8--g-4EIFQnPg05zDYewceAWA8ItDdfn4VPF8QMlaY8UBsanIfGCnoIUqFUr8mGdumlKjEifsS0rPmVdC8M_sBLRUWnM8ZRc3NNEy-OJu6sNKk6dinnbCjaNbhiyeXBxcGygVw1QsGyquQ0cxvH1ln3oXEn07vGfsz-_rx6vb8v7h5u7q8r702nBROmp6YRrjXCPqmrc1eENeuVq06FRO26NqqJMKOjRQd2RyNN-g1J732KI8Yz_3e1_i_G-ltNhxSJ5CcBPNa7JouMKamwye_wc-z2uccjYruJLQoJYZuthDPs4pRertSxxGF98scLut13KwuV57rNfu6rW0dfh-cFjbkbrj10OfGfhxAFzyLvTRTX5IRw6FMbCLqvbc6xwWiulvWF8p2g25sGy21koi16XIA0CWZb5SyHd955Ce</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204319653</pqid></control><display><type>article</type><title>Genetic Influence on Inflammation Variables in the Elderly</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>de Maat, Moniek P.M ; Bladbjerg, Else Marie ; Hjelmborg, Jacob von Bornemann ; Bathum, Lise ; Jespersen, Jørgen ; Christensen, Kaare</creator><creatorcontrib>de Maat, Moniek P.M ; Bladbjerg, Else Marie ; Hjelmborg, Jacob von Bornemann ; Bathum, Lise ; Jespersen, Jørgen ; Christensen, Kaare</creatorcontrib><description>BACKGROUND—Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables and of the acute phase regulating cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) at older ages.
METHODS AND RESULTS—The heritability of CRP, fibrinogen, sICAM-1, IL-6, and TNF-α was determined in a twin study consisting of 129 monozygotic twin pairs and 153 dizygotic same-sex twins aged 73 to 94 years who participated in the Longitudinal Study of Aging of Danish Twins. Furthermore, we determined the influence of selected genetic polymorphisms on the plasma level variations. Genetic factors accounted for 20% to 55% of the variation in plasma levels of the inflammation variables. The highest heritability was found for sICAM-1. The genetic polymorphisms we studied explained only a small, insignificant part of the heritability.
CONCLUSIONS—This study in elderly twins provides evidence for a substantial genetic component of inflammatory cardiovascular risk factors among the elderly.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.0000143856.01669.e7</identifier><identifier>PMID: 15345506</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Acute-Phase Proteins - metabolism ; Aged ; Aged, 80 and over ; Aging - genetics ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; Cytokines - blood ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Drug toxicity and drugs side effects treatment ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Inflammation - blood ; Inflammation - genetics ; Longitudinal Studies ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Phenotype ; Polymorphism, Genetic - genetics ; Population Surveillance ; Twin Studies as Topic - methods ; Twins, Dizygotic - genetics ; Twins, Monozygotic - genetics</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2004-11, Vol.24 (11), p.2168-2173</ispartof><rights>2004 American Heart Association, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Nov 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5702-ae9f2797aa92880b81c7ec4a82b6a4524f649ed341d6718de7455c9635c0f6b63</citedby><cites>FETCH-LOGICAL-c5702-ae9f2797aa92880b81c7ec4a82b6a4524f649ed341d6718de7455c9635c0f6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16277107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15345506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Maat, Moniek P.M</creatorcontrib><creatorcontrib>Bladbjerg, Else Marie</creatorcontrib><creatorcontrib>Hjelmborg, Jacob von Bornemann</creatorcontrib><creatorcontrib>Bathum, Lise</creatorcontrib><creatorcontrib>Jespersen, Jørgen</creatorcontrib><creatorcontrib>Christensen, Kaare</creatorcontrib><title>Genetic Influence on Inflammation Variables in the Elderly</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>BACKGROUND—Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables and of the acute phase regulating cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) at older ages.
METHODS AND RESULTS—The heritability of CRP, fibrinogen, sICAM-1, IL-6, and TNF-α was determined in a twin study consisting of 129 monozygotic twin pairs and 153 dizygotic same-sex twins aged 73 to 94 years who participated in the Longitudinal Study of Aging of Danish Twins. Furthermore, we determined the influence of selected genetic polymorphisms on the plasma level variations. Genetic factors accounted for 20% to 55% of the variation in plasma levels of the inflammation variables. The highest heritability was found for sICAM-1. The genetic polymorphisms we studied explained only a small, insignificant part of the heritability.
CONCLUSIONS—This study in elderly twins provides evidence for a substantial genetic component of inflammatory cardiovascular risk factors among the elderly.</description><subject>Acute-Phase Proteins - metabolism</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - genetics</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cytokines - blood</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - genetics</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population Surveillance</subject><subject>Twin Studies as Topic - methods</subject><subject>Twins, Dizygotic - genetics</subject><subject>Twins, Monozygotic - genetics</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3TAQhUVpadK0f6GYQLuzq9FjZGcXQpoEAtmk2QpZHnOdynYq2YT8--g-4EIFQnPg05zDYewceAWA8ItDdfn4VPF8QMlaY8UBsanIfGCnoIUqFUr8mGdumlKjEifsS0rPmVdC8M_sBLRUWnM8ZRc3NNEy-OJu6sNKk6dinnbCjaNbhiyeXBxcGygVw1QsGyquQ0cxvH1ln3oXEn07vGfsz-_rx6vb8v7h5u7q8r702nBROmp6YRrjXCPqmrc1eENeuVq06FRO26NqqJMKOjRQd2RyNN-g1J732KI8Yz_3e1_i_G-ltNhxSJ5CcBPNa7JouMKamwye_wc-z2uccjYruJLQoJYZuthDPs4pRertSxxGF98scLut13KwuV57rNfu6rW0dfh-cFjbkbrj10OfGfhxAFzyLvTRTX5IRw6FMbCLqvbc6xwWiulvWF8p2g25sGy21koi16XIA0CWZb5SyHd955Ce</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>de Maat, Moniek P.M</creator><creator>Bladbjerg, Else Marie</creator><creator>Hjelmborg, Jacob von Bornemann</creator><creator>Bathum, Lise</creator><creator>Jespersen, Jørgen</creator><creator>Christensen, Kaare</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200411</creationdate><title>Genetic Influence on Inflammation Variables in the Elderly</title><author>de Maat, Moniek P.M ; Bladbjerg, Else Marie ; Hjelmborg, Jacob von Bornemann ; Bathum, Lise ; Jespersen, Jørgen ; Christensen, Kaare</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5702-ae9f2797aa92880b81c7ec4a82b6a4524f649ed341d6718de7455c9635c0f6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute-Phase Proteins - metabolism</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - genetics</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cytokines - blood</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - genetics</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Population Surveillance</topic><topic>Twin Studies as Topic - methods</topic><topic>Twins, Dizygotic - genetics</topic><topic>Twins, Monozygotic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Maat, Moniek P.M</creatorcontrib><creatorcontrib>Bladbjerg, Else Marie</creatorcontrib><creatorcontrib>Hjelmborg, Jacob von Bornemann</creatorcontrib><creatorcontrib>Bathum, Lise</creatorcontrib><creatorcontrib>Jespersen, Jørgen</creatorcontrib><creatorcontrib>Christensen, Kaare</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Maat, Moniek P.M</au><au>Bladbjerg, Else Marie</au><au>Hjelmborg, Jacob von Bornemann</au><au>Bathum, Lise</au><au>Jespersen, Jørgen</au><au>Christensen, Kaare</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Influence on Inflammation Variables in the Elderly</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2004-11</date><risdate>2004</risdate><volume>24</volume><issue>11</issue><spage>2168</spage><epage>2173</epage><pages>2168-2173</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>BACKGROUND—Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables and of the acute phase regulating cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) at older ages.
METHODS AND RESULTS—The heritability of CRP, fibrinogen, sICAM-1, IL-6, and TNF-α was determined in a twin study consisting of 129 monozygotic twin pairs and 153 dizygotic same-sex twins aged 73 to 94 years who participated in the Longitudinal Study of Aging of Danish Twins. Furthermore, we determined the influence of selected genetic polymorphisms on the plasma level variations. Genetic factors accounted for 20% to 55% of the variation in plasma levels of the inflammation variables. The highest heritability was found for sICAM-1. The genetic polymorphisms we studied explained only a small, insignificant part of the heritability.
CONCLUSIONS—This study in elderly twins provides evidence for a substantial genetic component of inflammatory cardiovascular risk factors among the elderly.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>15345506</pmid><doi>10.1161/01.ATV.0000143856.01669.e7</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2004-11, Vol.24 (11), p.2168-2173 |
| issn | 1079-5642 1524-4636 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67046807 |
| source | Journals@Ovid Ovid Autoload; MEDLINE; Alma/SFX Local Collection |
| subjects | Acute-Phase Proteins - metabolism Aged Aged, 80 and over Aging - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Cytokines - blood Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug toxicity and drugs side effects treatment Female Genetic Predisposition to Disease - genetics Genotype Humans Inflammation - blood Inflammation - genetics Longitudinal Studies Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Phenotype Polymorphism, Genetic - genetics Population Surveillance Twin Studies as Topic - methods Twins, Dizygotic - genetics Twins, Monozygotic - genetics |
| title | Genetic Influence on Inflammation Variables in the Elderly |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A51%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Influence%20on%20Inflammation%20Variables%20in%20the%20Elderly&rft.jtitle=Arteriosclerosis,%20thrombosis,%20and%20vascular%20biology&rft.au=de%20Maat,%20Moniek%20P.M&rft.date=2004-11&rft.volume=24&rft.issue=11&rft.spage=2168&rft.epage=2173&rft.pages=2168-2173&rft.issn=1079-5642&rft.eissn=1524-4636&rft.coden=ATVBFA&rft_id=info:doi/10.1161/01.ATV.0000143856.01669.e7&rft_dat=%3Cproquest_cross%3E849744681%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204319653&rft_id=info:pmid/15345506&rfr_iscdi=true |