Selenium Levels in First-Degree Relatives of Diabetic Patients
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were...
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| Veröffentlicht in: | Biological trace element research 2009-05, Vol.128 (2), p.144-151 |
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| creator | Ozkaya, Mesut Sahin, Mustafa Cakal, Erman Gisi, Kadir Bilge, Fidan Kilinc, Metin |
| description | The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9 vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >= 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. |
| doi_str_mv | 10.1007/s12011-008-8263-z |
| format | Article |
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Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9 vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >= 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.]]></description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-008-8263-z</identifier><identifier>PMID: 18979071</identifier><language>eng</language><publisher>New York: New York : Humana Press Inc</publisher><subject>Adult ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood pressure ; Blood Pressure - physiology ; C-Reactive Protein - analysis ; Cardiovascular disease ; Cardiovascular diseases ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Female ; Health risks ; Homocysteine - blood ; Humans ; Insulin - blood ; Life Sciences ; Lipids - blood ; Male ; Middle Aged ; Nutrition ; Oncology ; Pedigree ; Risk factors ; Selenium ; Selenium - blood</subject><ispartof>Biological trace element research, 2009-05, Vol.128 (2), p.144-151</ispartof><rights>Humana Press Inc. 2008</rights><rights>Humana Press Inc. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-f38338b0826cb7d1c1f2d5b5659df0bc1f418e794f7cc13d5e73f60d919f5dc23</citedby><cites>FETCH-LOGICAL-c393t-f38338b0826cb7d1c1f2d5b5659df0bc1f418e794f7cc13d5e73f60d919f5dc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-008-8263-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-008-8263-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18979071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozkaya, Mesut</creatorcontrib><creatorcontrib>Sahin, Mustafa</creatorcontrib><creatorcontrib>Cakal, Erman</creatorcontrib><creatorcontrib>Gisi, Kadir</creatorcontrib><creatorcontrib>Bilge, Fidan</creatorcontrib><creatorcontrib>Kilinc, Metin</creatorcontrib><title>Selenium Levels in First-Degree Relatives of Diabetic Patients</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description><![CDATA[The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9 vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >= 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.]]></description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Female</subject><subject>Health risks</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Life Sciences</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Pedigree</subject><subject>Risk factors</subject><subject>Selenium</subject><subject>Selenium - blood</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFP3DAQha2qVdlSfgAXiDj0ljJjx7F9qYSgtJVWAhU4W4kzXhllE7ATJPj1GGUlpB56Gs34e8-jN4wdInxHAHWakANiCaBLzWtRvnxgK5TSlKA4fGQrwDysjK722JeU7gFQcSM-sz3URhlQuGI_bqinIczbYk1P1KciDMVliGkqL2gTiYq_1DdTeKJUjL64CE1LU3DFdZ7RMKWv7JNv-kQHu7rP7i5_3p7_LtdXv_6cn61LJ4yYSi-0ELqFvKVrVYcOPe9kK2tpOg9tbivUpEzllXMoOklK-Bo6g8bLznGxz74tvg9xfJwpTXYbkqO-bwYa52RrBVWNRmTw5B_wfpzjkHezHHXFUVYyQ7hALo4pRfL2IYZtE58tgn1L1i7J2pysfUvWvmTN0c54brfUvSt2UWaAL0DKT8OG4vvP_3M9XkS-GW2ziSHZu5sMiXw60Crf7xXnk4vD</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Ozkaya, Mesut</creator><creator>Sahin, Mustafa</creator><creator>Cakal, Erman</creator><creator>Gisi, Kadir</creator><creator>Bilge, Fidan</creator><creator>Kilinc, Metin</creator><general>New York : Humana Press Inc</general><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Selenium Levels in First-Degree Relatives of Diabetic Patients</title><author>Ozkaya, Mesut ; Sahin, Mustafa ; Cakal, Erman ; Gisi, Kadir ; Bilge, Fidan ; Kilinc, Metin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-f38338b0826cb7d1c1f2d5b5659df0bc1f418e794f7cc13d5e73f60d919f5dc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood pressure</topic><topic>Blood Pressure - 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Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkaya, Mesut</au><au>Sahin, Mustafa</au><au>Cakal, Erman</au><au>Gisi, Kadir</au><au>Bilge, Fidan</au><au>Kilinc, Metin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenium Levels in First-Degree Relatives of Diabetic Patients</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>128</volume><issue>2</issue><spage>144</spage><epage>151</epage><pages>144-151</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract><![CDATA[The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9 vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >= 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.]]></abstract><cop>New York</cop><pub>New York : Humana Press Inc</pub><pmid>18979071</pmid><doi>10.1007/s12011-008-8263-z</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biochemistry Biomedical and Life Sciences Biotechnology Blood pressure Blood Pressure - physiology C-Reactive Protein - analysis Cardiovascular disease Cardiovascular diseases Diabetes Diabetes Mellitus, Type 2 - blood Female Health risks Homocysteine - blood Humans Insulin - blood Life Sciences Lipids - blood Male Middle Aged Nutrition Oncology Pedigree Risk factors Selenium Selenium - blood |
| title | Selenium Levels in First-Degree Relatives of Diabetic Patients |
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