Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children
Summary This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway® (PLMA) insertion conditions in children. Eighty children, aged between 3–132 months, were ran...
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| Veröffentlicht in: | Anaesthesia 2009-03, Vol.64 (3), p.282-286 |
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| creator | Begec, Z. Demirbilek, S. Onal, D. Erdil, F. Ilksen Toprak, H. Ozcan Ersoy, M. |
| description | Summary
This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway® (PLMA) insertion conditions in children. Eighty children, aged between 3–132 months, were randomly allocated to receive either alfentanil 20 μg.kg−1 (alfentanil group) or ketamine 0.5 mg.kg−1 (ketamine group) before induction of anaesthesia. Ninety seconds following the administration of propofol 4 mg.kg−1, a PLMA was inserted. In the ketamine group, heart rate and mean arterial pressure were higher during the study period compared with the alfentanil group (p |
| doi_str_mv | 10.1111/j.1365-2044.2008.05782.x |
| format | Article |
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This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway® (PLMA) insertion conditions in children. Eighty children, aged between 3–132 months, were randomly allocated to receive either alfentanil 20 μg.kg−1 (alfentanil group) or ketamine 0.5 mg.kg−1 (ketamine group) before induction of anaesthesia. Ninety seconds following the administration of propofol 4 mg.kg−1, a PLMA was inserted. In the ketamine group, heart rate and mean arterial pressure were higher during the study period compared with the alfentanil group (p < 0.05). The time for the return of spontaneous ventilation was prolonged in the alfentanil group (p = 0.004). In conclusion, we found that the administration of ketamine 0.5 mg.kg−1 with propofol 4 mg.kg−1 preserved haemodynamic stability, and reduced the time to the return of spontaneous ventilation, compared with alfentanil 20 μg.kg−1 during PLMA placement. In addition, the conditions for insertion of the PLMA with ketamine were similar to those found with alfentanil.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2008.05782.x</identifier><identifier>PMID: 19302641</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Airway management ; Alfentanil - pharmacology ; Analgesics, Opioid - pharmacology ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Anesthetics, Intravenous - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Child ; Child, Preschool ; Clinical outcomes ; Drug therapy ; Female ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Humans ; Infant ; Intubation, Intratracheal - methods ; Ketamine - pharmacology ; Laryngeal Masks ; Male ; Medical sciences ; Pediatrics ; Preanesthetic Medication - methods ; Propofol - pharmacology ; Respiration - drug effects ; Surgery ; Ventilators</subject><ispartof>Anaesthesia, 2009-03, Vol.64 (3), p.282-286</ispartof><rights>2009 The Authors. Journal compilation © 2009 The Association of Anaesthetists of Great Britain and Ireland</rights><rights>2009 INIST-CNRS</rights><rights>2009 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4252-ed4713ac0c4317ba4d7c7d82513769986a7225805bb73bc9db2cd6b05bc48b0e3</citedby><cites>FETCH-LOGICAL-c4252-ed4713ac0c4317ba4d7c7d82513769986a7225805bb73bc9db2cd6b05bc48b0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2008.05782.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2008.05782.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21161233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19302641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begec, Z.</creatorcontrib><creatorcontrib>Demirbilek, S.</creatorcontrib><creatorcontrib>Onal, D.</creatorcontrib><creatorcontrib>Erdil, F.</creatorcontrib><creatorcontrib>Ilksen Toprak, H.</creatorcontrib><creatorcontrib>Ozcan Ersoy, M.</creatorcontrib><title>Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway® (PLMA) insertion conditions in children. Eighty children, aged between 3–132 months, were randomly allocated to receive either alfentanil 20 μg.kg−1 (alfentanil group) or ketamine 0.5 mg.kg−1 (ketamine group) before induction of anaesthesia. Ninety seconds following the administration of propofol 4 mg.kg−1, a PLMA was inserted. In the ketamine group, heart rate and mean arterial pressure were higher during the study period compared with the alfentanil group (p < 0.05). The time for the return of spontaneous ventilation was prolonged in the alfentanil group (p = 0.004). In conclusion, we found that the administration of ketamine 0.5 mg.kg−1 with propofol 4 mg.kg−1 preserved haemodynamic stability, and reduced the time to the return of spontaneous ventilation, compared with alfentanil 20 μg.kg−1 during PLMA placement. In addition, the conditions for insertion of the PLMA with ketamine were similar to those found with alfentanil.</description><subject>Airway management</subject><subject>Alfentanil - pharmacology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesiology</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical outcomes</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Infant</subject><subject>Intubation, Intratracheal - methods</subject><subject>Ketamine - pharmacology</subject><subject>Laryngeal Masks</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pediatrics</subject><subject>Preanesthetic Medication - methods</subject><subject>Propofol - pharmacology</subject><subject>Respiration - drug effects</subject><subject>Surgery</subject><subject>Ventilators</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAQxyMEokvhFZCFBLcN_kqccEBaVaUgKkACztbEdlgviV3srNq990l4AB6KJ2GyuyoSJ3yZGc9vRjPzLwrCaMnwvdyUTNTVklMpS05pU9JKNby8uVcs7hL3iwWlVCy5pO1J8SjnDaWMN6x5WJywVlBeS7Yofr13E4w-OBITgaF3YYLgBwIWP32eEkw-BnKVPOaniE68in1EIIDL09plD68IWuL63pkpE6Q_pfjZwfD79icZIO3CNwzICPk7AZ-uYUd8yC7tG5sYrJ-9jB0tWYMbo90FHMkQswYszUij6webXHhcPOhhyO7J0Z4WX9-cfzl7u7z8ePHubHW5NJJXfOmsVEyAoUYKpjqQVhllG14xoeq2bWpQnFcNrbpOic60tuPG1h3GRjYddeK0eHHoi_v-2OKievTZuGGA4OI261pRWVW1QPDZP-AmblPA2TRrlVBciRlqDpBJMefkeo33HPEymlE9C6o3etZNz7rpWVC9F1TfYOnTY_9tNzr7t_CoIALPjwBkgwImCMbnO44zVjO-n-H1gbv2g9v99wB69WF1PrviD79NwKs</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Begec, Z.</creator><creator>Demirbilek, S.</creator><creator>Onal, D.</creator><creator>Erdil, F.</creator><creator>Ilksen Toprak, H.</creator><creator>Ozcan Ersoy, M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children</title><author>Begec, Z. ; Demirbilek, S. ; Onal, D. ; Erdil, F. ; Ilksen Toprak, H. ; Ozcan Ersoy, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4252-ed4713ac0c4317ba4d7c7d82513769986a7225805bb73bc9db2cd6b05bc48b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Airway management</topic><topic>Alfentanil - pharmacology</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical outcomes</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Infant</topic><topic>Intubation, Intratracheal - methods</topic><topic>Ketamine - pharmacology</topic><topic>Laryngeal Masks</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pediatrics</topic><topic>Preanesthetic Medication - methods</topic><topic>Propofol - pharmacology</topic><topic>Respiration - drug effects</topic><topic>Surgery</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begec, Z.</creatorcontrib><creatorcontrib>Demirbilek, S.</creatorcontrib><creatorcontrib>Onal, D.</creatorcontrib><creatorcontrib>Erdil, F.</creatorcontrib><creatorcontrib>Ilksen Toprak, H.</creatorcontrib><creatorcontrib>Ozcan Ersoy, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begec, Z.</au><au>Demirbilek, S.</au><au>Onal, D.</au><au>Erdil, F.</au><au>Ilksen Toprak, H.</au><au>Ozcan Ersoy, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2009-03</date><risdate>2009</risdate><volume>64</volume><issue>3</issue><spage>282</spage><epage>286</epage><pages>282-286</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway® (PLMA) insertion conditions in children. Eighty children, aged between 3–132 months, were randomly allocated to receive either alfentanil 20 μg.kg−1 (alfentanil group) or ketamine 0.5 mg.kg−1 (ketamine group) before induction of anaesthesia. Ninety seconds following the administration of propofol 4 mg.kg−1, a PLMA was inserted. In the ketamine group, heart rate and mean arterial pressure were higher during the study period compared with the alfentanil group (p < 0.05). The time for the return of spontaneous ventilation was prolonged in the alfentanil group (p = 0.004). In conclusion, we found that the administration of ketamine 0.5 mg.kg−1 with propofol 4 mg.kg−1 preserved haemodynamic stability, and reduced the time to the return of spontaneous ventilation, compared with alfentanil 20 μg.kg−1 during PLMA placement. In addition, the conditions for insertion of the PLMA with ketamine were similar to those found with alfentanil.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19302641</pmid><doi>10.1111/j.1365-2044.2008.05782.x</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Free Content; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals |
| subjects | Airway management Alfentanil - pharmacology Analgesics, Opioid - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Anesthetics, Intravenous - pharmacology Biological and medical sciences Blood Pressure - drug effects Child Child, Preschool Clinical outcomes Drug therapy Female Heart Rate - drug effects Hemodynamics - drug effects Humans Infant Intubation, Intratracheal - methods Ketamine - pharmacology Laryngeal Masks Male Medical sciences Pediatrics Preanesthetic Medication - methods Propofol - pharmacology Respiration - drug effects Surgery Ventilators |
| title | Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children |
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