Complement activation and coagulation in xenotransplantation

Xenotransplantation using porcine donors holds tremendous promise for alleviating the chronic shortage of human organ donors. However, transplantation from pigs into higher primates triggers a vigorous immune response involving complement activation and thrombosis. Hyperacute rejection can be preven...

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Veröffentlicht in:	Immunology and cell biology 2009-03, Vol.87 (3), p.203-208
Hauptverfasser:	Cowan, Peter J, d'Apice, Anthony JF
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - immunology antibody Blood Coagulation - genetics Blood Coagulation - immunology coagulation complement Complement Activation - genetics Complement Activation - immunology endothelium Galactosyltransferases - genetics Galactosyltransferases - metabolism Graft Rejection - genetics Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival - genetics Humans Immune Tolerance - genetics Immunosuppression Primates Swine - genetics Swine - immunology thrombosis Transplantation, Heterologous - immunology xenograft
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