Hypochlorous Acid Impairs Endothelium-Derived Nitric Oxide Bioactivity Through a Superoxide-Dependent Mechanism

OBJECTIVE—To determine how hypochlorous acid (HOCl), the principal product of myeloperoxidase, modulates vascular function. METHODS AND RESULTS—Rabbit arterial rings exposed to HOCl (0 to 500 μmol/L) exhibited dose- and time-dependent impairment of endothelium-dependent arterial relaxation to acetyl...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-11, Vol.24 (11), p.2028-2033
Hauptverfasser:	Stocker, Roland, Huang, Annong, Jeranian, Erin, Hou, Jing Yun, Wu, Tina T, Thomas, Shane R, Keaney, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antioxidants - pharmacology Aorta - cytology Aorta - drug effects Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Survival - drug effects Cell Survival - genetics Cells, Cultured Coronary heart disease Dimerization Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Female Heart Hypochlorous Acid - pharmacology Male Medical sciences Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Proteins - immunology Proteins - metabolism Rabbits Staining and Labeling - methods Superoxides - metabolism Swine - genetics
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