Aberrant BRAF splicing as an alternative mechanism for oncogenic B-Raf activation in thyroid carcinoma

Activating BRAF mutations have recently been reported in 28-83% of papillary thyroid carcinomas (PTCs). However, it is not known whether aberrant BRAF splicing occurs in thyroid carcinoma. To investigate aberrant BRAF splicing and its association with BRAF mutation in thyroid tumours, we studied abe...

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Veröffentlicht in:	The Journal of pathology 2009-04, Vol.217 (5), p.707-715
Hauptverfasser:	Baitei, Essa Y, Zou, Minjing, Al-Mohanna, Futwan, Collison, Katharine, Alzahrani, Ali S, Farid, Nadir R, Meyer, Brian, Shi, Yufei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Base Sequence Biological and medical sciences BRAF Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology DNA, Neoplasm - genetics Endocrinopathies Enzyme Activation - genetics Humans Investigative techniques, diagnostic techniques (general aspects) Malignant tumors MAP Kinase Signaling System - genetics Medical sciences Middle Aged Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data mutation neoplasia Neoplasm Staging Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA Splicing - genetics RNA, Neoplasm - genetics splicing variant thyroid Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases)
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