Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phos...
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| Veröffentlicht in: | The FEBS journal 2009-04, Vol.276 (7), p.1790-1799 |
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| container_title | The FEBS journal |
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| creator | Baillie, George S |
| description | cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phosphodiesterases that act as sinks to create simultaneous, multiple cAMP gradients in many cellular locations. Such gradients are sampled within microdomains that contain anchored cAMP effector proteins. Compartmentalization of proteins that produce, degrade and are activated by cAMP is crucial for the specificity of action required for normal cell function. |
| doi_str_mv | 10.1111/j.1742-4658.2009.06926.x |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; IngentaConnect Free/Open Access Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry cAMP Cell Compartmentation - physiology Cellular biology Chemical synthesis compartmentalization compartmentalized signalling Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - analysis Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Cyclic Nucleotide-Gated Cation Channels - metabolism EPAC FRET G-protein coupled receptor Humans Models, Biological PDE PDE4 Phosphoric Diester Hydrolases - metabolism PKA Proteins Signal Transduction |
| title | Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases |
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