Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease
Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of mean corpuscular volume (MCV) in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative fac...
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| Veröffentlicht in: | Respiratory medicine 2004-11, Vol.98 (11), p.1117-1123 |
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| creator | Tsantes, Argirios E. Papadhimitriou, Stefanos I. Tassiopoulos, Stergios T. Bonovas, Stefanos Paterakis, George Meletis, Ioannis Loukopoulos, Dimitrios |
| description | Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of mean corpuscular volume (MCV) in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative factors, we evaluated the hematologic parameters, F-cell percentage, blood gases and serum erythropoietin (Epo) levels in 32 COPD clinically stable patients and 34 sex- and age-matched non-smoker healthy volunteers. An increased MCV was observed in almost half of the hypoxemic COPD cases (14/32 or 43.75%), while erythrocytosis developed to a lesser degree (37.5%). The erythropoietic response did not correlate with the severity of hypoxia. Moreover, no significant correlation was found between macrocytosis and hypoxemia or erythrocytosis and red cell size. In some cases the two phenomena occurred independently. The F-cell percentage was significantly elevated in the COPD group (
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| doi_str_mv | 10.1016/j.rmed.2004.04.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67041618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0954611104001556</els_id><sourcerecordid>67041618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-c54d1639d7d2a7c6f1f7d98d7e7420137c9ab768121668c64df09deb792dcb633</originalsourceid><addsrcrecordid>eNp9kF2r1DAQhoMonvXoH_BCAqJ3XZM0TVrw5nDwCw4Iot6GdDJls7RNTdKj--9N2UXBC2EgkHlmeOch5Dlne864enPcxwndXjAm91sx8YDseFOLqmZKPiQ71jWyUpzzK_IkpSNjrJOSPSZXvGmEanm9I9-_oKOA40gnCzHAKYfkE_UzPZyW8AsnD3Sx2eOcE_3p84HCIYa5_IY-5bhC9vdIl3WcwmzjiTqf0CZ8Sh4Ndkz47PJek2_v3329_Vjdff7w6fbmrgLZyFxBIx1Xdee0E1aDGvigXdc6jVoKxmsNne11SSq4Ui0o6QbWOex1Jxz0qq6vyevz3iWGHyumbCaftnPsjGFNRmkmueJtAV_-Ax7DGueSzXBWN0y2UqhCiTNVVKQUcTBL9FO5q0Bmc26OZnNuNudmKybK0IvL6rXfen9GLpIL8OoC2AR2HKKdwae_XMnXdGLj3p45LMbuPUaToIgHdD4iZOOC_1-O3znZn70</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035048426</pqid></control><display><type>article</type><title>Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Tsantes, Argirios E. ; Papadhimitriou, Stefanos I. ; Tassiopoulos, Stergios T. ; Bonovas, Stefanos ; Paterakis, George ; Meletis, Ioannis ; Loukopoulos, Dimitrios</creator><creatorcontrib>Tsantes, Argirios E. ; Papadhimitriou, Stefanos I. ; Tassiopoulos, Stergios T. ; Bonovas, Stefanos ; Paterakis, George ; Meletis, Ioannis ; Loukopoulos, Dimitrios</creatorcontrib><description>Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of mean corpuscular volume (MCV) in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative factors, we evaluated the hematologic parameters, F-cell percentage, blood gases and serum erythropoietin (Epo) levels in 32 COPD clinically stable patients and 34 sex- and age-matched non-smoker healthy volunteers. An increased MCV was observed in almost half of the hypoxemic COPD cases (14/32 or 43.75%), while erythrocytosis developed to a lesser degree (37.5%). The erythropoietic response did not correlate with the severity of hypoxia. Moreover, no significant correlation was found between macrocytosis and hypoxemia or erythrocytosis and red cell size. In some cases the two phenomena occurred independently. The F-cell percentage was significantly elevated in the COPD group (
P<0.01) and was associated with MCV values (
n=32,
r
s=0.41,
P<0.05). This finding supports the hypothesis we put forward to explain the macrocytosis often observed in COPD, i.e., that the acute erythropoietic stress occurring repeatedly in these patients as a result of the frequent exacerbations may lead to waves of release of relatively immature, large red cells from the marrow, including an increased number of F-cells, reflecting the recruitment of normally dormant BFU-E (bursts forming units of erythrocyte precursors), which maintain the program for
γ-chain synthesis. The fact that erythrocytosis and macrocytosis, both being triggered by hypoxemia, do not occur consistently in all COPD patients indicates that many other factors may also intervene.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2004.04.002</identifier><identifier>PMID: 15526813</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cellulose acetate ; Chronic obstructive pulmonary disease, asthma ; COPD ; Disease ; Erythrocytes, Abnormal ; Erythropoietic stress ; F-cells ; Female ; Humans ; Hypoxemia ; Hypoxia ; Hypoxia - blood ; Hypoxia - etiology ; Macrocytosis ; Male ; Medical sciences ; Middle Aged ; Oxygen - blood ; Partial Pressure ; Pneumology ; Polycythemia - etiology ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - complications ; Respiratory system : syndromes and miscellaneous diseases ; Standard deviation</subject><ispartof>Respiratory medicine, 2004-11, Vol.98 (11), p.1117-1123</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-c54d1639d7d2a7c6f1f7d98d7e7420137c9ab768121668c64df09deb792dcb633</citedby><cites>FETCH-LOGICAL-c454t-c54d1639d7d2a7c6f1f7d98d7e7420137c9ab768121668c64df09deb792dcb633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2004.04.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16185923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15526813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsantes, Argirios E.</creatorcontrib><creatorcontrib>Papadhimitriou, Stefanos I.</creatorcontrib><creatorcontrib>Tassiopoulos, Stergios T.</creatorcontrib><creatorcontrib>Bonovas, Stefanos</creatorcontrib><creatorcontrib>Paterakis, George</creatorcontrib><creatorcontrib>Meletis, Ioannis</creatorcontrib><creatorcontrib>Loukopoulos, Dimitrios</creatorcontrib><title>Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of mean corpuscular volume (MCV) in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative factors, we evaluated the hematologic parameters, F-cell percentage, blood gases and serum erythropoietin (Epo) levels in 32 COPD clinically stable patients and 34 sex- and age-matched non-smoker healthy volunteers. An increased MCV was observed in almost half of the hypoxemic COPD cases (14/32 or 43.75%), while erythrocytosis developed to a lesser degree (37.5%). The erythropoietic response did not correlate with the severity of hypoxia. Moreover, no significant correlation was found between macrocytosis and hypoxemia or erythrocytosis and red cell size. In some cases the two phenomena occurred independently. The F-cell percentage was significantly elevated in the COPD group (
P<0.01) and was associated with MCV values (
n=32,
r
s=0.41,
P<0.05). This finding supports the hypothesis we put forward to explain the macrocytosis often observed in COPD, i.e., that the acute erythropoietic stress occurring repeatedly in these patients as a result of the frequent exacerbations may lead to waves of release of relatively immature, large red cells from the marrow, including an increased number of F-cells, reflecting the recruitment of normally dormant BFU-E (bursts forming units of erythrocyte precursors), which maintain the program for
γ-chain synthesis. The fact that erythrocytosis and macrocytosis, both being triggered by hypoxemia, do not occur consistently in all COPD patients indicates that many other factors may also intervene.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cellulose acetate</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>COPD</subject><subject>Disease</subject><subject>Erythrocytes, Abnormal</subject><subject>Erythropoietic stress</subject><subject>F-cells</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxemia</subject><subject>Hypoxia</subject><subject>Hypoxia - blood</subject><subject>Hypoxia - etiology</subject><subject>Macrocytosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxygen - blood</subject><subject>Partial Pressure</subject><subject>Pneumology</subject><subject>Polycythemia - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Standard deviation</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2r1DAQhoMonvXoH_BCAqJ3XZM0TVrw5nDwCw4Iot6GdDJls7RNTdKj--9N2UXBC2EgkHlmeOch5Dlne864enPcxwndXjAm91sx8YDseFOLqmZKPiQ71jWyUpzzK_IkpSNjrJOSPSZXvGmEanm9I9-_oKOA40gnCzHAKYfkE_UzPZyW8AsnD3Sx2eOcE_3p84HCIYa5_IY-5bhC9vdIl3WcwmzjiTqf0CZ8Sh4Ndkz47PJek2_v3329_Vjdff7w6fbmrgLZyFxBIx1Xdee0E1aDGvigXdc6jVoKxmsNne11SSq4Ui0o6QbWOex1Jxz0qq6vyevz3iWGHyumbCaftnPsjGFNRmkmueJtAV_-Ax7DGueSzXBWN0y2UqhCiTNVVKQUcTBL9FO5q0Bmc26OZnNuNudmKybK0IvL6rXfen9GLpIL8OoC2AR2HKKdwae_XMnXdGLj3p45LMbuPUaToIgHdD4iZOOC_1-O3znZn70</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Tsantes, Argirios E.</creator><creator>Papadhimitriou, Stefanos I.</creator><creator>Tassiopoulos, Stergios T.</creator><creator>Bonovas, Stefanos</creator><creator>Paterakis, George</creator><creator>Meletis, Ioannis</creator><creator>Loukopoulos, Dimitrios</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease</title><author>Tsantes, Argirios E. ; Papadhimitriou, Stefanos I. ; Tassiopoulos, Stergios T. ; Bonovas, Stefanos ; Paterakis, George ; Meletis, Ioannis ; Loukopoulos, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-c54d1639d7d2a7c6f1f7d98d7e7420137c9ab768121668c64df09deb792dcb633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cellulose acetate</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>COPD</topic><topic>Disease</topic><topic>Erythrocytes, Abnormal</topic><topic>Erythropoietic stress</topic><topic>F-cells</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxemia</topic><topic>Hypoxia</topic><topic>Hypoxia - blood</topic><topic>Hypoxia - etiology</topic><topic>Macrocytosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxygen - blood</topic><topic>Partial Pressure</topic><topic>Pneumology</topic><topic>Polycythemia - etiology</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Standard deviation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsantes, Argirios E.</creatorcontrib><creatorcontrib>Papadhimitriou, Stefanos I.</creatorcontrib><creatorcontrib>Tassiopoulos, Stergios T.</creatorcontrib><creatorcontrib>Bonovas, Stefanos</creatorcontrib><creatorcontrib>Paterakis, George</creatorcontrib><creatorcontrib>Meletis, Ioannis</creatorcontrib><creatorcontrib>Loukopoulos, Dimitrios</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsantes, Argirios E.</au><au>Papadhimitriou, Stefanos I.</au><au>Tassiopoulos, Stergios T.</au><au>Bonovas, Stefanos</au><au>Paterakis, George</au><au>Meletis, Ioannis</au><au>Loukopoulos, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>98</volume><issue>11</issue><spage>1117</spage><epage>1123</epage><pages>1117-1123</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of mean corpuscular volume (MCV) in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative factors, we evaluated the hematologic parameters, F-cell percentage, blood gases and serum erythropoietin (Epo) levels in 32 COPD clinically stable patients and 34 sex- and age-matched non-smoker healthy volunteers. An increased MCV was observed in almost half of the hypoxemic COPD cases (14/32 or 43.75%), while erythrocytosis developed to a lesser degree (37.5%). The erythropoietic response did not correlate with the severity of hypoxia. Moreover, no significant correlation was found between macrocytosis and hypoxemia or erythrocytosis and red cell size. In some cases the two phenomena occurred independently. The F-cell percentage was significantly elevated in the COPD group (
P<0.01) and was associated with MCV values (
n=32,
r
s=0.41,
P<0.05). This finding supports the hypothesis we put forward to explain the macrocytosis often observed in COPD, i.e., that the acute erythropoietic stress occurring repeatedly in these patients as a result of the frequent exacerbations may lead to waves of release of relatively immature, large red cells from the marrow, including an increased number of F-cells, reflecting the recruitment of normally dormant BFU-E (bursts forming units of erythrocyte precursors), which maintain the program for
γ-chain synthesis. The fact that erythrocytosis and macrocytosis, both being triggered by hypoxemia, do not occur consistently in all COPD patients indicates that many other factors may also intervene.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15526813</pmid><doi>10.1016/j.rmed.2004.04.002</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cellulose acetate Chronic obstructive pulmonary disease, asthma COPD Disease Erythrocytes, Abnormal Erythropoietic stress F-cells Female Humans Hypoxemia Hypoxia Hypoxia - blood Hypoxia - etiology Macrocytosis Male Medical sciences Middle Aged Oxygen - blood Partial Pressure Pneumology Polycythemia - etiology Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - complications Respiratory system : syndromes and miscellaneous diseases Standard deviation |
| title | Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease |
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