The unfolded protein response during prostate cancer development

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). The UPR promotes cell survival by adjusting ER protein folding capacity but if homeostasis cannot be re-established, apoptosis is induced. The execution of life/death decisions is regula...

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Veröffentlicht in:	Cancer and metastasis reviews 2009-06, Vol.28 (1-2), p.219-223
Hauptverfasser:	So, Alex Yick-Lun, de la Fuente, Erwin, Walter, Peter, Shuman, Marc, Bernales, Sebastián
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Membrane - metabolism Disease Models, Animal Endoplasmic Reticulum - metabolism Gene Expression Regulation, Neoplastic Humans Male Medical sciences Mice Mice, Transgenic Models, Biological Nephrology. Urinary tract diseases Non-Thematic Review Oligonucleotide Array Sequence Analysis - methods Oncology Prostatic Neoplasms - metabolism Protein Denaturation Protein Folding Signal Transduction Tumors Tumors of the urinary system Urinary tract. Prostate gland
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