Simple, sensitive and rapid LC–MS/MS method for the quantitation of cerivastatin in human plasma — application to pharmacokinetic studies

A simple and sensitive liquid chromatography–tandem mass spectrometry method was developed and validated for estimation of cerivastatin (I) in human plasma, a potent hydroxy-methylglutaryl-coenzyme A reductase inhibitor. The analyte and internal standard (atorvastatin, II) were extracted by liquid/l...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2004-11, Vol.36 (3), p.505-515
Hauptverfasser:	Ramakrishna, N.V.S., Koteshwara, M., Vishwottam, K.N., Puran, S., Manoj, S., Santosh, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Cerivastatin Chromatography, Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology HMG-CoA reductase inhibitor Humans LC–MS/MS Mass Spectrometry - methods Medical sciences Pharmacology. Drug treatments Pyridines - blood Pyridines - chemistry Pyridines - pharmacokinetics Sensitivity and Specificity
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