Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways

cAMP responsive element binding protein (CREB) is a stimulus induced transcription factor with possible relevance for the pathophysiology of the heart. In the present study, we provide evidence that the hypertrophic agonist, phenylephrine (PE), promotes phosphorylation of CREB in adult rat cardiac m...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2004-11, Vol.37 (5), p.1001-1011
Hauptverfasser:	Markou, Thomais, Hadzopoulou-Cladaras, Margarita, Lazou, Antigone
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic agonist Adrenergic Agonists - pharmacology Adrenergic alpha-1 Receptor Agonists Adult rat cardiac myocytes ANF Animals Atrial Natriuretic Factor - genetics Cardiomegaly - genetics CREB CREB-Binding Protein Cyclic AMP Response Element-Binding Protein - immunology Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - physiology Gene Expression Regulation - drug effects Hypertrophy Immunoprecipitation Indoles - pharmacology Isoquinolines - pharmacology MAPK Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - physiology MSK1 Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Nuclear Proteins - immunology Nuclear Proteins - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Phenylephrine - pharmacology Phosphorylation - drug effects Rats Receptors, Adrenergic, alpha-1 - physiology Receptors, Adrenergic, beta - physiology Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors Ribosomal Protein S6 Kinases, 90-kDa - physiology RNA, Messenger - analysis RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sulfonamides - pharmacology Trans-Activators - immunology Trans-Activators - metabolism Transcription factor
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