Compartmentalized signalling: Ca²⁺ compartments, microdomains and the many facets of Ca²⁺ signalling

Ca²⁺ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca²⁺ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how...

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Veröffentlicht in:	The FEBS journal 2009-04, Vol.276 (7), p.1800-1816
Hauptverfasser:	Laude, Alex J, Simpson, Alec W.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Calcium Calcium - metabolism Calcium Signaling - physiology calcium store Cell Compartmentation - physiology Cell Nucleus - metabolism Cellular biology CICR compartmentalized cyclic ADP-ribose Cytoplasm - metabolism Humans inositol trisphosphate receptor Membrane Microdomains - metabolism microdomains Mitochondria - metabolism Models, Biological NADP (coenzyme) nicotinamide adenine dinucleotide phosphate organelle ryanodine intracellular receptor Signal Transduction
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