Computational and Biochemical Identification of a Nuclear Pore Complex Binding Site on the Nuclear Transport Carrier NTF2

Nuclear transport carriers interact with proteins of the nuclear pore complex (NPC) to transport their cargo across the nuclear envelope. One such carrier is nuclear transport factor 2 (NTF2), whose import cargo is the small GTPase Ran. A domain highly homologous to the small NTF2 protein (14 kDa) i...

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Veröffentlicht in:Journal of molecular biology 2004-11, Vol.344 (2), p.303-310
Hauptverfasser: Cushman, Ian, Bowman, Brian R., Sowa, Mathew E., Lichtarge, Olivier, Quiocho, Florante A., Moore, Mary Shannon
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Sprache:eng
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