Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer

The psychological impact of predictive genetic testing for hereditary non‐polyposis colorectal cancer (HNPCC) was assessed in 114 individuals (32 carriers and 82 non‐carriers) attending familial cancer clinics, using mailed self‐administered questionnaires prior to, 2 weeks, 4 months and 12 months a...

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Veröffentlicht in:	Clinical genetics 2004-12, Vol.66 (6), p.502-511
Hauptverfasser:	Meiser, B, Collins, V, Warren, R, Gaff, C, St John, DJB, Young, M-A, Harrop, K, Brown, J, Halliday, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety - etiology Anxiety - psychology Biological and medical sciences Cancer Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - psychology Depression - etiology Depression - psychology Female General aspects. Genetic counseling Genetic testing Genetic Testing - psychology hereditary non-polyposis colorectal cancer Heterozygote Humans Male Medical genetics Medical sciences Psychological aspects psychological impact Stress, Psychological - etiology Surveys and Questionnaires
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Zusammenfassung:	The psychological impact of predictive genetic testing for hereditary non‐polyposis colorectal cancer (HNPCC) was assessed in 114 individuals (32 carriers and 82 non‐carriers) attending familial cancer clinics, using mailed self‐administered questionnaires prior to, 2 weeks, 4 months and 12 months after carrier status disclosure. Compared to baseline, carriers showed a significant increase in mean scores for intrusive and avoidant thoughts about colorectal cancer 2 weeks (t = 2.49; p = 0.014) and a significant decrease in mean depression scores 2 weeks post‐notification of result (t = −3.98; p
ISSN:	0009-9163 1399-0004
DOI:	10.1111/j.1399-0004.2004.00339.x