Involvement of p53 and Fas/CD95 in murine neural progenitor cell response to ionizing irradiation

We investigated the role of tumor suppressor p53 and Fas (CD95/APO-1), a member of the tumor necrosis factor receptor family, in neural progenitors response to γ -irradiation exposure. Telencephalic cells were obtained from wild-type C57Bl/6, or p53 −/− or fas −/−, 15-day-old mouse embryos. They wer...

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Veröffentlicht in:	Oncogene 2004-11, Vol.23 (52), p.8497-8508
Hauptverfasser:	Semont, Alexandra, Nowak, Ewa B, Silva Lages, Céline, Mathieu, Céline, Mouthon, Marc-André, May, Evelyne, Allemand, Isabelle, Millet, Pascal, Boussin, François D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Apoptosis - physiology Apoptosis - radiation effects Biological and medical sciences CD95 antigen Cell Biology Cell cycle Cell Cycle - physiology Cell Cycle - radiation effects Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-dependent kinase inhibitor p21 Embryos fas Receptor - metabolism Fundamental and applied biological sciences. Psychology Gamma Rays Gene expression Human Genetics Internal Medicine Ionizing radiation Localization Medicine Medicine & Public Health Mice Molecular and cellular biology Monoclonal antibodies Nervous system Neural stem cells Neurospheres Oncology original-paper p53 Protein Progenitor cells Radiation Receptors, Tumor Necrosis Factor - metabolism Signal transduction Signal Transduction - physiology Stem cells Stem Cells - metabolism Stem Cells - radiation effects Telencephalon Tumor necrosis factor-TNF Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism γ Radiation
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