SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells
Abstract The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression...
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| Veröffentlicht in: | Cancer letters 2009-05, Vol.277 (1), p.29-37 |
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| container_title | Cancer letters |
| container_volume | 277 |
| creator | Zhang, Yu Huang, Shuyan Dong, Wei Li, Lin Feng, Yunpeng Pan, Lina Han, Zhenkun Wang, Xiuli Ren, Guoling Su, Dongmei Huang, Baiqu Lu, Jun |
| description | Abstract The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity. |
| doi_str_mv | 10.1016/j.canlet.2008.11.014 |
| format | Article |
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Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2008.11.014</identifier><identifier>PMID: 19108950</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Apoptosis ; beta Catenin - antagonists & inhibitors ; Cell growth ; Cell Line, Tumor ; Cell Proliferation ; Cloning ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - prevention & control ; Deoxyribonucleic acid ; Disclosure ; DNA ; DNA methylation ; Down-Regulation ; Epigenesis, Genetic ; Gene expression ; Gene Silencing ; Hematology, Oncology and Palliative Medicine ; Humans ; Proteins ; SOX7 ; SOXF Transcription Factors - antagonists & inhibitors ; SOXF Transcription Factors - genetics ; SOXF Transcription Factors - physiology ; Transcription factors ; Wnt pathway</subject><ispartof>Cancer letters, 2009-05, Vol.277 (1), p.29-37</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited May 8, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-766bf40ab41534ac3befdbbae84fa2286194f17d6941f695f698812bc2fd44483</citedby><cites>FETCH-LOGICAL-c509t-766bf40ab41534ac3befdbbae84fa2286194f17d6941f695f698812bc2fd44483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2008.11.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19108950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Huang, Shuyan</creatorcontrib><creatorcontrib>Dong, Wei</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Feng, Yunpeng</creatorcontrib><creatorcontrib>Pan, Lina</creatorcontrib><creatorcontrib>Han, Zhenkun</creatorcontrib><creatorcontrib>Wang, Xiuli</creatorcontrib><creatorcontrib>Ren, Guoling</creatorcontrib><creatorcontrib>Su, Dongmei</creatorcontrib><creatorcontrib>Huang, Baiqu</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><title>SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity.</description><subject>Apoptosis</subject><subject>beta Catenin - antagonists & inhibitors</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cloning</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Deoxyribonucleic acid</subject><subject>Disclosure</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Down-Regulation</subject><subject>Epigenesis, Genetic</subject><subject>Gene expression</subject><subject>Gene Silencing</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Proteins</subject><subject>SOX7</subject><subject>SOXF Transcription Factors - antagonists & inhibitors</subject><subject>SOXF Transcription Factors - genetics</subject><subject>SOXF Transcription Factors - physiology</subject><subject>Transcription factors</subject><subject>Wnt pathway</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1r3DAQFaWh2ab9B6UYCj3Fzowt29KlUEK_IJBDUuhNyPKo1VZrbSW7Jf--cnchkB5yEBrEmzdP7w1jrxAqBOwutpXRk6e5qgFEhVgB8idsg6Kvy14KeMo20AAvG9G0p-x5SlsAaHnfPmOnKBGEbGHD4s31t_68GMOfqYz0ffF6prFwU2GCD5HMrH2R5xiK5_l1XAylQu_Dfg7J5WpasT_c4OZU7GPwzlLUswtTEez_FIUh79MLdmK1T_TyeJ-xrx8_3F5-Lq-uP325fH9VmhbkXPZdN1gOeuDYNlybZiA7DoMmwa2ua9Gh5Bb7sZMcbSfbfITAejC1HTnnojljbw-8WdivhdKsdi6tCvREYUmq66GRbb8C3zwAbsMSp6xNYZstE9ggzyh-QJkYUopk1T66nY53CkGtiaitOiSi1kQUooJ_ba-P5Muwo_G-6RhBBrw7ACh78dtRVMk4ynaNbjVPjcE9NuEhgfFuckb7n3RH6f4vKtUK1M26FetSgMgkMld_Acv0s9Y</recordid><startdate>20090508</startdate><enddate>20090508</enddate><creator>Zhang, Yu</creator><creator>Huang, Shuyan</creator><creator>Dong, Wei</creator><creator>Li, Lin</creator><creator>Feng, Yunpeng</creator><creator>Pan, Lina</creator><creator>Han, Zhenkun</creator><creator>Wang, Xiuli</creator><creator>Ren, Guoling</creator><creator>Su, Dongmei</creator><creator>Huang, Baiqu</creator><creator>Lu, Jun</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20090508</creationdate><title>SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells</title><author>Zhang, Yu ; Huang, Shuyan ; Dong, Wei ; Li, Lin ; Feng, Yunpeng ; Pan, Lina ; Han, Zhenkun ; Wang, Xiuli ; Ren, Guoling ; Su, Dongmei ; Huang, Baiqu ; Lu, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-766bf40ab41534ac3befdbbae84fa2286194f17d6941f695f698812bc2fd44483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Apoptosis</topic><topic>beta Catenin - antagonists & inhibitors</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Cloning</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Deoxyribonucleic acid</topic><topic>Disclosure</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Down-Regulation</topic><topic>Epigenesis, Genetic</topic><topic>Gene expression</topic><topic>Gene Silencing</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Proteins</topic><topic>SOX7</topic><topic>SOXF Transcription Factors - antagonists & inhibitors</topic><topic>SOXF Transcription Factors - genetics</topic><topic>SOXF Transcription Factors - physiology</topic><topic>Transcription factors</topic><topic>Wnt pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Huang, Shuyan</creatorcontrib><creatorcontrib>Dong, Wei</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Feng, Yunpeng</creatorcontrib><creatorcontrib>Pan, Lina</creatorcontrib><creatorcontrib>Han, Zhenkun</creatorcontrib><creatorcontrib>Wang, Xiuli</creatorcontrib><creatorcontrib>Ren, Guoling</creatorcontrib><creatorcontrib>Su, Dongmei</creatorcontrib><creatorcontrib>Huang, Baiqu</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yu</au><au>Huang, Shuyan</au><au>Dong, Wei</au><au>Li, Lin</au><au>Feng, Yunpeng</au><au>Pan, Lina</au><au>Han, Zhenkun</au><au>Wang, Xiuli</au><au>Ren, Guoling</au><au>Su, Dongmei</au><au>Huang, Baiqu</au><au>Lu, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2009-05-08</date><risdate>2009</risdate><volume>277</volume><issue>1</issue><spage>29</spage><epage>37</epage><pages>29-37</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19108950</pmid><doi>10.1016/j.canlet.2008.11.014</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| subjects | Apoptosis beta Catenin - antagonists & inhibitors Cell growth Cell Line, Tumor Cell Proliferation Cloning Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Deoxyribonucleic acid Disclosure DNA DNA methylation Down-Regulation Epigenesis, Genetic Gene expression Gene Silencing Hematology, Oncology and Palliative Medicine Humans Proteins SOX7 SOXF Transcription Factors - antagonists & inhibitors SOXF Transcription Factors - genetics SOXF Transcription Factors - physiology Transcription factors Wnt pathway |
| title | SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells |
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