CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes

ABSTRACT Human neutrophil granulocytes die rapidly, and their survival is contingent upon rescue from programmed cell death by signals from the environment. We now show that a novel signal for delaying neutrophil apoptosis is unmethylated CpG motifs prevalent in bacterial DNA (CpG‐DNA). Human neutro...

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Veröffentlicht in:	The FASEB journal 2004-11, Vol.18 (14), p.1776-1778
Hauptverfasser:	József, Levente, Khreiss, Tarek, Filep, János G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Bacteria bcl-Associated Death Protein Carrier Proteins - metabolism caspase-3 Caspases - metabolism Cell Survival CpG Islands Cytochromes c - metabolism DNA, Bacterial - chemistry DNA, Bacterial - pharmacology DNA-Binding Proteins - metabolism Endosomes - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Humans Hydrogen-Ion Concentration inflammation Kinetics Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology mitochondrial dysfunction neutrophil survival Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Receptors, Cell Surface - metabolism Toll-Like Receptor 9
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