Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects
Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Par...
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| Veröffentlicht in: | British journal of nutrition 2004-10, Vol.92 (4), p.649-655 |
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| creator | Paschos, George K. Rallidis, Loukianos S. Liakos, Georgios K. Panagiotakos, Demosthenes Anastasiadis, George Votteas, Vasilios Zampelas, Antonis |
| description | Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P |
| doi_str_mv | 10.1079/BJN20041230 |
| format | Article |
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We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P<0·001), CRP (P=0·002), MCSF (P=0·005) and IL-6 (P=0·04) concentrations. The Mediterranean–Cretan-type background diet group showed a significant reduction only in MCSF concentrations (P=0·003). The sVCAM-1 concentrations were significantly reduced in both the Westernised Greek diet group (P=0·001) and the Mediterranean–Cretan-type diet group (P<0·001). The present study demonstrated that ALA supplementation lowered the serum concentrations of inflammatory markers more profoundly when the background diet was rich in saturated fatty acids and poor in MUFA.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20041230</identifier><identifier>PMID: 15522134</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; alpha-Linolenic Acid - therapeutic use ; Biological and medical sciences ; Biomarkers - blood ; Cell Adhesion Molecules - blood ; Cellular adhesion molecules ; Diet ; Diet, Mediterranean ; Dietary Supplements ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - diet therapy ; Inflammation - blood ; Inflammation - diet therapy ; Inflammatory markers ; Male ; Medical sciences ; Mediterranean diet ; Metabolic diseases ; Middle Aged ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; α-Linolenic acid</subject><ispartof>British journal of nutrition, 2004-10, Vol.92 (4), p.649-655</ispartof><rights>Copyright © The Nutrition Society 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-490e9b8d877c206733f2e428dbb00dddacfe053a038d4b6e498dbafbade717a83</citedby><cites>FETCH-LOGICAL-c452t-490e9b8d877c206733f2e428dbb00dddacfe053a038d4b6e498dbafbade717a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16199928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15522134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paschos, George K.</creatorcontrib><creatorcontrib>Rallidis, Loukianos S.</creatorcontrib><creatorcontrib>Liakos, Georgios K.</creatorcontrib><creatorcontrib>Panagiotakos, Demosthenes</creatorcontrib><creatorcontrib>Anastasiadis, George</creatorcontrib><creatorcontrib>Votteas, Vasilios</creatorcontrib><creatorcontrib>Zampelas, Antonis</creatorcontrib><title>Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P<0·001), CRP (P=0·002), MCSF (P=0·005) and IL-6 (P=0·04) concentrations. The Mediterranean–Cretan-type background diet group showed a significant reduction only in MCSF concentrations (P=0·003). The sVCAM-1 concentrations were significantly reduced in both the Westernised Greek diet group (P=0·001) and the Mediterranean–Cretan-type diet group (P<0·001). The present study demonstrated that ALA supplementation lowered the serum concentrations of inflammatory markers more profoundly when the background diet was rich in saturated fatty acids and poor in MUFA.</description><subject>Adult</subject><subject>alpha-Linolenic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Cellular adhesion molecules</subject><subject>Diet</subject><subject>Diet, Mediterranean</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - diet therapy</subject><subject>Inflammation - blood</subject><subject>Inflammation - diet therapy</subject><subject>Inflammatory markers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mediterranean diet</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>α-Linolenic acid</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9u1DAQhyMEokvhxB1ygUuVMrbjODnSCgqoFFW0XK2JPV68zZ_FTiT2sXgRnqle7YrtgZPlmW9-mvmy7CWDUwaqeXf25YoDlIwLeJQtWKlkwauKP84WAKAKxkp5lD2LcZW-NYPmaXbEpOSciXKRuTM0d8swzoPNracp94PrZhoMxXz6STkOky-2Nex7nMawyck5MlM-uvzvn6Lzw9jR4E2Oxts0nNtN7PzaW6Q-VePcrhIdn2dPHHaRXuzf4-z244eb80_F5beLz-fvLwtTSj4VZQPUtLWtlTIcKiWE41Ty2rYtgLUWjSOQAkHUtmwrKpvUQteiJcUU1uI4e7vLXYfx10xx0r2PhroOBxrnqCuVRpOHBJ7sQBPGGAM5vQ6-x7DRDPRWq36gNdGv9rFz25M9sHuPCXizBzAa7FzAwfh44CrWNA3f7lfsOB8n-v2vj-EurSaU1NXFtRby6vorYz_0TeJf73iHo8ZlSJm33zkwAQy4hEYeEg32bfB2SXo1zmFIlv97yj3fA6e3</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Paschos, George K.</creator><creator>Rallidis, Loukianos S.</creator><creator>Liakos, Georgios K.</creator><creator>Panagiotakos, Demosthenes</creator><creator>Anastasiadis, George</creator><creator>Votteas, Vasilios</creator><creator>Zampelas, Antonis</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects</title><author>Paschos, George K. ; Rallidis, Loukianos S. ; Liakos, Georgios K. ; Panagiotakos, Demosthenes ; Anastasiadis, George ; Votteas, Vasilios ; Zampelas, Antonis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-490e9b8d877c206733f2e428dbb00dddacfe053a038d4b6e498dbafbade717a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>alpha-Linolenic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Cellular adhesion molecules</topic><topic>Diet</topic><topic>Diet, Mediterranean</topic><topic>Dietary Supplements</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - diet therapy</topic><topic>Inflammation - blood</topic><topic>Inflammation - diet therapy</topic><topic>Inflammatory markers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mediterranean diet</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>α-Linolenic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paschos, George K.</creatorcontrib><creatorcontrib>Rallidis, Loukianos S.</creatorcontrib><creatorcontrib>Liakos, Georgios K.</creatorcontrib><creatorcontrib>Panagiotakos, Demosthenes</creatorcontrib><creatorcontrib>Anastasiadis, George</creatorcontrib><creatorcontrib>Votteas, Vasilios</creatorcontrib><creatorcontrib>Zampelas, Antonis</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paschos, George K.</au><au>Rallidis, Loukianos S.</au><au>Liakos, Georgios K.</au><au>Panagiotakos, Demosthenes</au><au>Anastasiadis, George</au><au>Votteas, Vasilios</au><au>Zampelas, Antonis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>92</volume><issue>4</issue><spage>649</spage><epage>655</epage><pages>649-655</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P<0·001), CRP (P=0·002), MCSF (P=0·005) and IL-6 (P=0·04) concentrations. The Mediterranean–Cretan-type background diet group showed a significant reduction only in MCSF concentrations (P=0·003). The sVCAM-1 concentrations were significantly reduced in both the Westernised Greek diet group (P=0·001) and the Mediterranean–Cretan-type diet group (P<0·001). The present study demonstrated that ALA supplementation lowered the serum concentrations of inflammatory markers more profoundly when the background diet was rich in saturated fatty acids and poor in MUFA.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15522134</pmid><doi>10.1079/BJN20041230</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult alpha-Linolenic Acid - therapeutic use Biological and medical sciences Biomarkers - blood Cell Adhesion Molecules - blood Cellular adhesion molecules Diet Diet, Mediterranean Dietary Supplements Humans Hyperlipidemias - blood Hyperlipidemias - diet therapy Inflammation - blood Inflammation - diet therapy Inflammatory markers Male Medical sciences Mediterranean diet Metabolic diseases Middle Aged Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) α-Linolenic acid |
| title | Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects |
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