Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride
Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model. About a...
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| Veröffentlicht in: | Transplantation proceedings 2004-09, Vol.36 (7), p.1928-1930 |
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| creator | Chung, K.Y. Jeong, G.Y. Choi, K.B. Sung, S.H. Kim, Y.S. |
| description | Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model.
About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group,
n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (
n = 5). Statistical analysis was done with an independent
t-test.
Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (
P = .03) and LDH (
P = .05) levels were significantly lower in the gadolinium group.
Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion. |
| doi_str_mv | 10.1016/j.transproceed.2004.09.006 |
| format | Article |
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About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group,
n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (
n = 5). Statistical analysis was done with an independent
t-test.
Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (
P = .03) and LDH (
P = .05) levels were significantly lower in the gadolinium group.
Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.09.006</identifier><identifier>PMID: 15518701</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Dogs ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gadolinium - therapeutic use ; Kupffer Cells - drug effects ; Kupffer Cells - pathology ; L-Lactate Dehydrogenase - blood ; Liver Function Tests ; Liver Transplantation - methods ; Liver Transplantation - physiology ; Medical sciences ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Transplantation, Homologous</subject><ispartof>Transplantation proceedings, 2004-09, Vol.36 (7), p.1928-1930</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-5e3dfc5e1ad562afa8d6a57e5b69941bbdd6d9d23a256e496ab1df8e42f111aa3</citedby><cites>FETCH-LOGICAL-c406t-5e3dfc5e1ad562afa8d6a57e5b69941bbdd6d9d23a256e496ab1df8e42f111aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134504010668$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16271365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15518701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, K.Y.</creatorcontrib><creatorcontrib>Jeong, G.Y.</creatorcontrib><creatorcontrib>Choi, K.B.</creatorcontrib><creatorcontrib>Sung, S.H.</creatorcontrib><creatorcontrib>Kim, Y.S.</creatorcontrib><title>Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model.
About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group,
n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (
n = 5). Statistical analysis was done with an independent
t-test.
Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (
P = .03) and LDH (
P = .05) levels were significantly lower in the gadolinium group.
Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gadolinium - therapeutic use</subject><subject>Kupffer Cells - drug effects</subject><subject>Kupffer Cells - pathology</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver Function Tests</subject><subject>Liver Transplantation - methods</subject><subject>Liver Transplantation - physiology</subject><subject>Medical sciences</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi1ERZfCX0AREtwS_BE7m95Q-apUqRzK2ZrYY-rFaxc7Wan_Hi8bAUdO1nieGb9-CHnNaMcoU-923ZwhloecDKLtOKV9R8eOUvWEbNh2EC1XXDwlm9pgLRO9PCfPS9nRWvNePCPnTMrKUbYhP75mPGCcfYpNcs1D9nvIj01M0S3R_L4GN2NuDEQfsQn-UAsIIZ0yBIgzHLHL5u4eG3QOzXzc9B1sCj76Zd-Y-5Cyt_iCnDkIBV-u5wX59unj3dWX9ub28_XV-5vW9FTNrURhnZHIwErFwcHWKpADykmNY8-myVplR8sFcKmwHxVMzLot9twxxgDEBXl72lsN_VywzHrvi8FQs2JailYDFQNnqoKXJ9DkVEpGp9f_a0b1UbXe6X9V66NqTUddVdfhV-sry7SvvT-jq9sKvFkBKAaCq4uML385xQcmlKzchxOH1cnBY9bFeIwGrc9VprbJ_0-eXwF4pz8</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Chung, K.Y.</creator><creator>Jeong, G.Y.</creator><creator>Choi, K.B.</creator><creator>Sung, S.H.</creator><creator>Kim, Y.S.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride</title><author>Chung, K.Y. ; Jeong, G.Y. ; Choi, K.B. ; Sung, S.H. ; Kim, Y.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-5e3dfc5e1ad562afa8d6a57e5b69941bbdd6d9d23a256e496ab1df8e42f111aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gadolinium - therapeutic use</topic><topic>Kupffer Cells - drug effects</topic><topic>Kupffer Cells - pathology</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver Function Tests</topic><topic>Liver Transplantation - methods</topic><topic>Liver Transplantation - physiology</topic><topic>Medical sciences</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, K.Y.</creatorcontrib><creatorcontrib>Jeong, G.Y.</creatorcontrib><creatorcontrib>Choi, K.B.</creatorcontrib><creatorcontrib>Sung, S.H.</creatorcontrib><creatorcontrib>Kim, Y.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, K.Y.</au><au>Jeong, G.Y.</au><au>Choi, K.B.</au><au>Sung, S.H.</au><au>Kim, Y.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>36</volume><issue>7</issue><spage>1928</spage><epage>1930</epage><pages>1928-1930</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model.
About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group,
n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (
n = 5). Statistical analysis was done with an independent
t-test.
Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (
P = .03) and LDH (
P = .05) levels were significantly lower in the gadolinium group.
Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15518701</pmid><doi>10.1016/j.transproceed.2004.09.006</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Dogs Fundamental and applied biological sciences. Psychology Fundamental immunology Gadolinium - therapeutic use Kupffer Cells - drug effects Kupffer Cells - pathology L-Lactate Dehydrogenase - blood Liver Function Tests Liver Transplantation - methods Liver Transplantation - physiology Medical sciences Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transplantation, Homologous |
| title | Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride |
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