In vitro assembly into virus-like particles is an intrinsic quality of Pichia pastoris derived HCV core protein

Different variants of hepatitis C virus core protein (HCcAg) have proved to self-assemble in vitro into virus-like particles (VLPs). However, difficulties in obtaining purified mature HCcAg have limited these studies. In this study, a high degree of monomeric HCcAg purification was accomplished usin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-12, Vol.325 (1), p.68-74
Hauptverfasser:	Acosta-Rivero, Nelson, Rodriguez, Armando, Musacchio, Alexis, Falcón, Viviana, Suarez, Viana M., Martinez, Gillian, Guerra, Ivis, Paz-Lago, Dalila, Morera, Yanelys, de la Rosa, María C., Morales-Grillo, Juan, Dueñas-Carrera, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Capsid - chemistry Capsid - ultrastructure Core antigen Hepatitis C Hepatitis C virus Humans Particle Size Pichia - chemistry Pichia pastoris Protein Conformation Viral Core Proteins - chemistry Viral Core Proteins - isolation & purification Viral Core Proteins - metabolism Viral Core Proteins - ultrastructure Virus-like particles
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