Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry

A sensitive liquid chromatography-electrospray ionization tandem mass spectrometry method (LC/ESI/MS/MS) for the enantioselective determination of (S)-(+)-BMS-204352, a potent and specific maxi-K channel opener, in human, rat and dog plasma was developed. (S)-(+)-BMS-204352, its enantiomer (R)-(--)-...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2004-11, Vol.811 (2), p.109-117
Hauptverfasser:	JIANING ZENG, PALME, Holly, SRINIVAS, Nuggehally, ARNOLD, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Calibration Dogs Fundamental and applied biological sciences. Psychology General pharmacology Humans Indoles - blood Mass Spectrometry - methods Medical sciences Neuroprotective Agents - blood Pharmacology. Drug treatments Rats Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Stereoisomerism
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