Rational Design of Multitargeted Tyrosine Kinase Inhibitors: A Novel Approach

The non-receptor Src tyrosine kinase is known to cooperate with the epidermal growth factor receptor in a mechanism leading to invasion and metastasis of solid tumours. With the purpose of developing agents targeted to both epidermal growth factor receptor and Src or related kinases, we embarked on...

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Veröffentlicht in:	Chemical biology & drug design 2009-04, Vol.73 (4), p.380-387
Hauptverfasser:	Barchéchath, Sylvie, Williams, Christopher, Saade, Khalil, Lauwagie, Sylvia, Jean-Claude, Bertrand
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Drug Design Humans Ligands mechanism-based drug design Models, Molecular Protein Binding Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - metabolism Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - metabolism Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolines - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - chemistry src-Family Kinases - metabolism structure-based drug
Online-Zugang:	Volltext
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