Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome

The Ts65Dn mouse is a genetic model for Down syndrome. Although this mouse shows abnormalities in cognitive function that implicate hippocampus as well as marked deficits in hippocampal long‐term potentiation, the structure of the hippocampus has been little studied. We characterized synaptic struct...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2004-12, Vol.480 (3), p.281-298
Hauptverfasser:	Belichenko, Pavel V., Masliah, Eliezer, Kleschevnikov, Alexander M., Villar, Angela J., Epstein, Charles J., Salehi, Ahmad, Mobley, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - pathology Brain - ultrastructure Dendritic Spines - ultrastructure Disease Models, Animal Down syndrome Down Syndrome - pathology Female Hippocampus - pathology Hippocampus - ultrastructure Male Mice Mice, Inbred C57BL Mice, Neurologic Mutants morphometry Motor Cortex - pathology Motor Cortex - ultrastructure Presynaptic Terminals - ultrastructure Reference Values Somatosensory Cortex - pathology Somatosensory Cortex - ultrastructure spines synapses Synapses - ultrastructure Ts65Dn
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