Slurred speech and spirochaetes

Blood tests showed anaemia (113 g/L), deranged coagulation profile (platelets 95×10. per L; INR 1?33; and APTT 45 s), and high serum concentrations of alkaline phosphatase (587 IU/L), aspartate aminotransferase (203 IU/L), and alanine aminotransferase (133 IU/L) MRI of the brain was within normal li...

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Veröffentlicht in:The Lancet (British edition) 2009-03, Vol.373 (9667), p.978-978
Hauptverfasser: Thukral, Anubhav, Dr, Khan, Imran, MD, Tripathi, Kamlakar, Prof
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Sprache:eng
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Zusammenfassung:Blood tests showed anaemia (113 g/L), deranged coagulation profile (platelets 95×10. per L; INR 1?33; and APTT 45 s), and high serum concentrations of alkaline phosphatase (587 IU/L), aspartate aminotransferase (203 IU/L), and alanine aminotransferase (133 IU/L) MRI of the brain was within normal limits. Neuroleptospirosis occurs in about 2% of patients, with aseptic meningitis being the most common neuro logical manifestation.2 Other presentations include myeloradiculopathy, myelopathy, Guillain-Barré syn drome-like presentation, meningoencephalitis, intra cerebral bleeding, cerebellar dysfunction, iridocyclitis, and tremor or rigidity.3 Cerebellar involvement occurs in about 3% of neuroleptospirosis cases.2 Neuroleptospirosis is under diagnosed, especially in an-icteric forms.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(09)60288-9