Amyloid Abeta1-40 preconditions non-apoptotic signals in vivo and protects fetal rat brain from intrauterine ischemic stress

Abstract The dualistic activities of the amyloid beta (Abeta) peptide as a pro-oxidant and ubiquitous constituent of amyloid deposits in Alzheimer's disease plaques and as an antioxidant of purported physiological function has been suggested but the mechanisms are far from being understood. In...

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Veröffentlicht in:	Journal of neurochemistry 2004-11, Vol.91 (4), p.965-974
Hauptverfasser:	Kuperstein, Faina, Brand, Annette, Yavin, Ephraim
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - pharmacokinetics Amyloid beta-Peptides - pharmacology Animals Apoptosis - drug effects Biomarkers - metabolism Brain - drug effects Brain - embryology Brain - metabolism Brain Ischemia - metabolism Brain Ischemia - physiopathology Brain Ischemia - prevention & control Caspases - metabolism Cell Survival - drug effects Female Fetus Hypotension - physiopathology Hypovolemia - physiopathology Injections, Intraperitoneal Maternal-Fetal Exchange - physiology Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Peptide Fragments - pharmacokinetics Peptide Fragments - pharmacology Pregnancy Rats Rats, Wistar Signal Transduction - drug effects
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