The role of the AT1 angiotensin receptor in cardiac hypertrophy: angiotensin II receptor or stretch sensor?

Activation of the AT(1) angiotensin receptor is a clinically important maladaptive response during cardiac hypertrophy. Autocrine and paracrine effects of locally generated angiotensin II, are believed to be the main mediators of these responses. However, a recent report has suggested that mechanica...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2004-11, Vol.15 (9), p.405-408
Hauptverfasser:	HUNYADY, Laszlo, TURU, Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cardiomegaly - physiopathology Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Medical sciences Myocardial Contraction - physiology Receptor, Angiotensin, Type 1 - physiology Receptors, Angiotensin - physiology Stress, Mechanical
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