Tau pathophysiology in neurodegeneration: a tangled issue
Neurodegenerative tauopathies are marked by their common pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated with synapse and neuronal loss. Changes in tau conformation result in both loss of normal function and gain of fibrillogenicity that leads to aggr...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2009-03, Vol.32 (3), p.150-159 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Spires-Jones, Tara L Stoothoff, William H de Calignon, Alix Jones, Phillip B Hyman, Bradley T |
| description | Neurodegenerative tauopathies are marked by their common pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated with synapse and neuronal loss. Changes in tau conformation result in both loss of normal function and gain of fibrillogenicity that leads to aggregation. Here, we discuss the pathophysiology of tau and emerging evidence of how changes in this protein might ultimately lead to neuronal death. In particular, based on recent evidence, we propose that a non-apoptotic caspase-associated form of death is occurring in tauopathy. |
| doi_str_mv | 10.1016/j.tins.2008.11.007 |
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| ispartof | Trends in neurosciences (Regular ed.), 2009-03, Vol.32 (3), p.150-159 |
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| subjects | Animals Apoptosis Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology Humans Medical sciences Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Nerve Degeneration - genetics Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurology Neurons Neurosciences Proteases Proteins tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - pathology Tauopathies - physiopathology Vertebrates: nervous system and sense organs |
| title | Tau pathophysiology in neurodegeneration: a tangled issue |
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