Confidence intervals for ratios of AUCs in the case of serial sampling: a comparison of seven methods

Pharmacokinetic studies are commonly performed using the two‐stage approach. The first stage involves estimation of pharmacokinetic parameters such as the area under the concentration versus time curve (AUC) for each analysis subject separately, and the second stage uses the individual parameter est...

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Veröffentlicht in:	Pharmaceutical statistics : the journal of the pharmaceutical industry 2009-01, Vol.8 (1), p.12-24
Hauptverfasser:	Jaki, Thomas, Wolfsegger, Martin J., Ploner, Meinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve AUC bioequivalence bootstrap Confidence Intervals Data Interpretation, Statistical Humans Pharmacokinetics Research Design Sample Size serial sacrifice design serial sampling design sparse sampling Therapeutic Equivalency
Online-Zugang:	Volltext
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