Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis. Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease dev...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2004-11, Vol.44 (9), p.1812-1818 |
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| creator | Deo, Rajat Khera, Amit McGuire, Darren K. Murphy, Sabina A. de P. Meo Neto, Januario Morrow, David A. de Lemos, James A. |
| description | We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis.
Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.
In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.
Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p < 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.
In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development. |
| doi_str_mv | 10.1016/j.jacc.2004.07.047 |
| format | Article |
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Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.
In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.
Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p &lt; 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.
In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2004.07.047</identifier><identifier>PMID: 15519012</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Adult ; Age ; Age Factors ; Aged ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood pressure ; Bone density ; C-Reactive Protein - metabolism ; Calcium - metabolism ; Cardiology ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Chemokine CCL2 - blood ; Cholesterol ; Cholesterol, HDL - metabolism ; Cholesterol, LDL - metabolism ; Confidence intervals ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Vessels - metabolism ; Diabetes ; Family medical history ; Female ; Heart ; Heart rate ; Humans ; Hypertension ; Male ; Medical sciences ; Middle Aged ; Plasma ; Population ; Proteins ; Risk Factors ; Statistics as Topic ; Studies ; Texas ; Tomography ; Tomography, X-Ray Computed ; Triglycerides - metabolism ; Veins & arteries</subject><ispartof>Journal of the American College of Cardiology, 2004-11, Vol.44 (9), p.1812-1818</ispartof><rights>2004 American College of Cardiology Foundation</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 2, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-8951c53481e0a155aaeca647f34aace86d44cf715636f37803c58d852140c9813</citedby><cites>FETCH-LOGICAL-c555t-8951c53481e0a155aaeca647f34aace86d44cf715636f37803c58d852140c9813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2004.07.047$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16268141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15519012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deo, Rajat</creatorcontrib><creatorcontrib>Khera, Amit</creatorcontrib><creatorcontrib>McGuire, Darren K.</creatorcontrib><creatorcontrib>Murphy, Sabina A.</creatorcontrib><creatorcontrib>de P. Meo Neto, Januario</creatorcontrib><creatorcontrib>Morrow, David A.</creatorcontrib><creatorcontrib>de Lemos, James A.</creatorcontrib><title>Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis.
Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.
In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.
Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p &lt; 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.
In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.</description><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Bone density</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcium - metabolism</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Chemokine CCL2 - blood</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Confidence intervals</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Vessels - metabolism</subject><subject>Diabetes</subject><subject>Family medical history</subject><subject>Female</subject><subject>Heart</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Population</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><subject>Studies</subject><subject>Texas</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Triglycerides - metabolism</subject><subject>Veins & arteries</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqFTEUhgdR7G31BVxIQHTVGZNJMslAN6VYFQpudB1Oz2RsxszkmmQu9Cl8ZTPcCwUXbhI4fP8hf76qesNowyjrPk7NBIhNS6loqGqoUM-qHZNS11z26nm1o4rLmtFenVXnKU2U0k6z_mV1ViDWU9buqj_XKQV0kF1YCMxh-Un2HtIMxNuD9YmEkZRpwMdsCT7YOUDOETDDksk-hmzdUrNLUmaD25aAJwhxcOEACVcPkUSXfpGxREJMlwSWgaT1Hr1bHBYY8oONIaHfTpdeVS9G8Mm-Pt0X1Y_bT99vvtR33z5_vbm-q1FKmWvdS4aSC80shdIGwCJ0Qo1cAKDV3SAEjorJjncjV5pylHrQsmWCYq8Zv6g-HPeWDr9Xm7KZXULrPSw2rMl0inLG2r6A7_4Bp7DGUjMZJmnHZKu5KFR7pLC0SNGOZh_dDPHRMGo2WWYymyyzyTJUmSKrhN6eVq_3sx2eIic7BXh_Aspfgh8jLOjSE9e1xafYylwduSLMHpyNJqGzC9rBRYvZDMH97x1_AS4itKs</recordid><startdate>20041102</startdate><enddate>20041102</enddate><creator>Deo, Rajat</creator><creator>Khera, Amit</creator><creator>McGuire, Darren K.</creator><creator>Murphy, Sabina A.</creator><creator>de P. 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Vascular system</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Chemokine CCL2 - blood</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - metabolism</topic><topic>Cholesterol, LDL - metabolism</topic><topic>Confidence intervals</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Vessels - metabolism</topic><topic>Diabetes</topic><topic>Family medical history</topic><topic>Female</topic><topic>Heart</topic><topic>Heart rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Population</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Statistics as Topic</topic><topic>Studies</topic><topic>Texas</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Triglycerides - metabolism</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deo, Rajat</creatorcontrib><creatorcontrib>Khera, Amit</creatorcontrib><creatorcontrib>McGuire, Darren K.</creatorcontrib><creatorcontrib>Murphy, Sabina A.</creatorcontrib><creatorcontrib>de P. 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Meo Neto, Januario</au><au>Morrow, David A.</au><au>de Lemos, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2004-11-02</date><risdate>2004</risdate><volume>44</volume><issue>9</issue><spage>1812</spage><epage>1818</epage><pages>1812-1818</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis.
Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.
In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.
Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p &lt; 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.
In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15519012</pmid><doi>10.1016/j.jacc.2004.07.047</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndromes Adult Age Age Factors Aged Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood pressure Bone density C-Reactive Protein - metabolism Calcium - metabolism Cardiology Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - epidemiology Chemokine CCL2 - blood Cholesterol Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Confidence intervals Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Vessels - metabolism Diabetes Family medical history Female Heart Heart rate Humans Hypertension Male Medical sciences Middle Aged Plasma Population Proteins Risk Factors Statistics as Topic Studies Texas Tomography Tomography, X-Ray Computed Triglycerides - metabolism Veins & arteries |
| title | Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis |
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