The nature of stem cells: state rather than entity
Stem cells are endowed with self-renewal and multipotential differentiation capacities. Contrary to the expectation that stem cells would selectively express specific genes, these cells have a highly promiscuous gene-expression pattern. Here, I suggest that the transient stem cell state, termed the...
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| Veröffentlicht in: | Nature reviews. Genetics 2004-11, Vol.5 (11), p.873-878 |
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| creator | Zipori, Dov |
| description | Stem cells are endowed with self-renewal and multipotential differentiation capacities. Contrary to the expectation that stem cells would selectively express specific genes, these cells have a highly promiscuous gene-expression pattern. Here, I suggest that the transient stem cell state, termed the 'stem state', may be assumed by any cell and that the search for specific genes expressed by all stem cells, which would characterize the stem cell as a cell type, might be futile. |
| doi_str_mv | 10.1038/nrg1475 |
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Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zipori, Dov</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nature of stem cells: state rather than entity</atitle><jtitle>Nature reviews. Genetics</jtitle><stitle>Nat Rev Genet</stitle><addtitle>Nat Rev Genet</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>5</volume><issue>11</issue><spage>873</spage><epage>878</epage><pages>873-878</pages><issn>1471-0056</issn><eissn>1471-0064</eissn><abstract>Stem cells are endowed with self-renewal and multipotential differentiation capacities. Contrary to the expectation that stem cells would selectively express specific genes, these cells have a highly promiscuous gene-expression pattern. 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| subjects | Agriculture Animal Genetics and Genomics Biobanks Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Differentiation Ethics Exceptionalism Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Function Genetic research Genetic testing Genetics of eukaryotes. Biological and molecular evolution Genomes Genomics Human Genetics Humans Informed consent opinion-2 Phenotype Population genetics Science Stem cells Stem Cells - cytology Stem Cells - metabolism |
| title | The nature of stem cells: state rather than entity |
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