Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 has been shown to be prevalently overexpressed in human breast cancer cell lines and cancer tissue...

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Veröffentlicht in:	Oncology reports 2009-04, Vol.21 (4), p.1097-1104
Hauptverfasser:	LEUNG, Kam-Wing, TSAI, Chen-Hsun, HSIAO, Michael, TSENG, Ching-Juinn, GER, Luo-Ping, LEE, Kuen-Haur, LU, Pei-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged beta Catenin - analysis Biological and medical sciences Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Differentiation Cell Survival Cyclin D1 - analysis Humans Immunohistochemistry Medical sciences Middle Aged Mouth Neoplasms - chemistry Mouth Neoplasms - mortality Mouth Neoplasms - pathology NIMA-Interacting Peptidylprolyl Isomerase Otorhinolaryngology. Stomatology Peptidylprolyl Isomerase - analysis Peptidylprolyl Isomerase - physiology Prognosis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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