Failed adoptive immunotherapy with tumor-specific T cells: Reversal with low-dose interleukin 15 but not low-dose interleukin 2

Adoptive immunotherapy with tumor-specific T cells has emerged as a valid approach for prevention or treatment of diseases, such as melanoma and EBV-associated lymphoma. As interleukin (IL) 15 promotes survival of CD8(+) memory CTLs, we hypothesized that it could be used to enhance antitumor immunit...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-11, Vol.64 (21), p.8062-8067
Hauptverfasser:	ROYCHOWDHURY, Sameek, MAY, Kenneth F, TZOU, Katherine S, LIN, Teresa, BHATT, Darshna, FREUD, Aharon G, GUIMOND, Martin, FERKETICH, Amy K, YANG LIU, CALIGIURI, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Female Immunologic Memory Immunotherapy, Adoptive Interleukin-15 - therapeutic use Interleukin-2 - therapeutic use Lymphocyte Activation Medical sciences Mice Mice, Inbred BALB C Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - analysis T-Lymphocytes - immunology Tumors
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