Effect of pH on radiation-induced p53 expression

In most tumors, the intratumor environment is acidic. The purpose of this study was to elucidate the effect of acidic extracellular environment on the radiation-induced expression of p53 and related molecular signals. Cultured RKO.C human colorectal cancer cells carrying wild-type p53 were used. Cel...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2004-11, Vol.60 (4), p.1264-1271
Hauptverfasser:	Choi, Eun Kyung, Roberts, Kenneth P., Griffin, Robert J., Han, TaeHee, Park, Heon-Jin, Song, Chang Won, Park, Heon Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic environment Biological and medical sciences Cell Line, Tumor - metabolism Culture Media - chemistry Humans Hydrogen-Ion Concentration Mdm2 Medical sciences p53 Phosphorylation Radiation Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) RNA, Messenger - metabolism Technology. Biomaterials. Equipments. Material. Instrumentation Time Factors Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - radiation effects
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