Purinergic signaling in special senses
We consider the impact of purinergic signaling on the physiology of the special senses of vision, smell, taste and hearing. Purines (particularly ATP and adenosine) act as neurotransmitters, gliotransmitters and paracrine factors in the sensory retina, nasal olfactory epithelium, taste buds and coch...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2009-03, Vol.32 (3), p.128-141 |
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| creator | Housley, Gary D Bringmann, Andreas Reichenbach, Andreas |
| description | We consider the impact of purinergic signaling on the physiology of the special senses of vision, smell, taste and hearing. Purines (particularly ATP and adenosine) act as neurotransmitters, gliotransmitters and paracrine factors in the sensory retina, nasal olfactory epithelium, taste buds and cochlea. The associated purinergic receptor signaling underpins the sensory transduction and information coding in these sense organs. The P2 and P1 receptors mediate fast transmission of sensory signals and have modulatory roles in the regulation of synaptic transmitter release, for example in the adaptation to sensory overstimulation. Purinergic signaling regulates bidirectional neuron–glia interactions and is involved in the control of blood supply, extracellular ion homeostasis and the turnover of sensory epithelia by modulating apoptosis and progenitor proliferation. Purinergic signaling is an important player in pathophysiological processes in sensory tissues, and has both detrimental (pro-apoptotic) and supportive (e.g. initiation of cytoprotective stress-signaling cascades) effects. |
| doi_str_mv | 10.1016/j.tins.2009.01.001 |
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Purines (particularly ATP and adenosine) act as neurotransmitters, gliotransmitters and paracrine factors in the sensory retina, nasal olfactory epithelium, taste buds and cochlea. The associated purinergic receptor signaling underpins the sensory transduction and information coding in these sense organs. The P2 and P1 receptors mediate fast transmission of sensory signals and have modulatory roles in the regulation of synaptic transmitter release, for example in the adaptation to sensory overstimulation. Purinergic signaling regulates bidirectional neuron–glia interactions and is involved in the control of blood supply, extracellular ion homeostasis and the turnover of sensory epithelia by modulating apoptosis and progenitor proliferation. Purinergic signaling is an important player in pathophysiological processes in sensory tissues, and has both detrimental (pro-apoptotic) and supportive (e.g. initiation of cytoprotective stress-signaling cascades) effects.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2009.01.001</identifier><identifier>PMID: 19232752</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adenosine triphosphatase ; Afferent Pathways - anatomy & histology ; Afferent Pathways - physiology ; Animals ; Apoptosis ; Biological and medical sciences ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. 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Purines (particularly ATP and adenosine) act as neurotransmitters, gliotransmitters and paracrine factors in the sensory retina, nasal olfactory epithelium, taste buds and cochlea. The associated purinergic receptor signaling underpins the sensory transduction and information coding in these sense organs. The P2 and P1 receptors mediate fast transmission of sensory signals and have modulatory roles in the regulation of synaptic transmitter release, for example in the adaptation to sensory overstimulation. Purinergic signaling regulates bidirectional neuron–glia interactions and is involved in the control of blood supply, extracellular ion homeostasis and the turnover of sensory epithelia by modulating apoptosis and progenitor proliferation. Purinergic signaling is an important player in pathophysiological processes in sensory tissues, and has both detrimental (pro-apoptotic) and supportive (e.g. initiation of cytoprotective stress-signaling cascades) effects.</description><subject>Adenosine triphosphatase</subject><subject>Afferent Pathways - anatomy & histology</subject><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Neurotransmitters</subject><subject>Purines - metabolism</subject><subject>Receptors, Purinergic - physiology</subject><subject>Sensation - physiology</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkGL1DAUx4Mo7rj6BTzIILi31veStGlABFlcFRYU3IO3kKavQ8ZOO-ZNF_bbmzrDCnvQUy6__z95vzwhXiKUCFi_3ZaHOHIpAWwJWALgI7HCxjQFQvPjsVhlqC6kVPWZeMa8zYBuUD8VZ2ilkqaSK3HxbU5xpLSJYc1xM_ohjpt1HNe8pxD9sGYamfi5eNL7genF6TwXN1cfby4_F9dfP325_HBdBG3Noahs3ZmqrlRjTdNq1WjTa2U1WbJ95xGC1EqB1Z0JQFWHXY-y7QHa1gMqdS4ujrX7NP2aiQ9uFznQMPiRppldbUDa3PpfUILGCv-Arx-A22lOeczMZFVZQ20yJI9QSBNzot7tU9z5dOcQ3KLabd2i2i2qHaDLJnPo1al5bnfU_Y2c3GbgzQnwHPzQJz-GyPecRFVpZRbu3ZGjLPY2UnIcIo2BupgoHFw3xX-_4_2DeMh_GPONP-mO-H5cdCwduO_LUiw7ARYApGzUbzjXrjk</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Housley, Gary D</creator><creator>Bringmann, Andreas</creator><creator>Reichenbach, Andreas</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Purinergic signaling in special senses</title><author>Housley, Gary D ; Bringmann, Andreas ; Reichenbach, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-596d756538978b43847f4394e9e9fda10c2433094d7c0e5d1df12bf00bba0133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenosine triphosphatase</topic><topic>Afferent Pathways - anatomy & histology</topic><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Neurotransmitters</topic><topic>Purines - metabolism</topic><topic>Receptors, Purinergic - physiology</topic><topic>Sensation - physiology</topic><topic>Signal transduction</topic><topic>Signal Transduction - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Housley, Gary D</creatorcontrib><creatorcontrib>Bringmann, Andreas</creatorcontrib><creatorcontrib>Reichenbach, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Housley, Gary D</au><au>Bringmann, Andreas</au><au>Reichenbach, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purinergic signaling in special senses</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><addtitle>Trends Neurosci</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>32</volume><issue>3</issue><spage>128</spage><epage>141</epage><pages>128-141</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><coden>TNSCDR</coden><abstract>We consider the impact of purinergic signaling on the physiology of the special senses of vision, smell, taste and hearing. 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| subjects | Adenosine triphosphatase Afferent Pathways - anatomy & histology Afferent Pathways - physiology Animals Apoptosis Biological and medical sciences Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Neurology Neurons Neurosciences Neurotransmitters Purines - metabolism Receptors, Purinergic - physiology Sensation - physiology Signal transduction Signal Transduction - physiology Vertebrates: nervous system and sense organs |
| title | Purinergic signaling in special senses |
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