Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?

Objectives Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites. We investigated how ratios changed over time and which urine collection interval would be the best for NAT2 and XO activity assessments. Methods...

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Veröffentlicht in:	European journal of clinical pharmacology 2009-04, Vol.65 (4), p.411-417
Hauptverfasser:	Jetter, Alexander, Kinzig, Martina, Rodamer, Michael, Tomalik-Scharte, Dorota, Sörgel, Fritz, Fuhr, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adult Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Arylamine N-Acetyltransferase - urine Biological and medical sciences Biomedical and Life Sciences Biomedicine Caffeine Caffeine - administration & dosage Caffeine - pharmacology Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Enzymes European Continental Ancestry Group - genetics Genotype & phenotype Humans Intra-individual variability Male Medical sciences N-acetyltransferase 2 Pharmacokinetics and Disposition Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Phenotype Phenotyping Polymorphism Time Factors Uracil - analogs & derivatives Uracil - urine Uric Acid - analogs & derivatives Uric Acid - urine Urinalysis xanthine oxidase Xanthine Oxidase - genetics Xanthine Oxidase - metabolism Xanthine Oxidase - urine Xanthines - urine
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