Locally Applied Isosorbide Decreases Bone Resorption in Experimental Periodontitis in Rats

Background: The role of nitric oxide (NO) on bone metabolism is controversial, since it can either stimulate bone formation or resorption. We investigated the effect of local administration of the NO donor isosorbide in an experimental periodontal disease model. Methods: Wistar rats were subjected t...

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Veröffentlicht in:	Journal of periodontology (1970) 2004-09, Vol.75 (9), p.1227-1232
Hauptverfasser:	Leitão, R.F.C., Rocha, F.A.C., Chaves, H.V., Lima, V., Cunha, F.Q., Ribeiro, R.A., Brito, G.A.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Bone Loss - pathology Alveolar Bone Loss - prevention & control Alveolar Process - drug effects Alveolar Process - pathology Animal studies Animals bone and bones/metabolism bone resorption/prevention and control Dental Cementum - drug effects Dental Cementum - pathology Dentin - drug effects Dentin - pathology Dentistry Disease Models, Animal Gingiva - drug effects Gingiva - pathology Isosorbide - therapeutic use Molar - pathology nitric acid Nitric Oxide Donors - therapeutic use Periodontal Ligament - drug effects Periodontal Ligament - pathology Periodontitis - prevention & control Pharmaceutical Vehicles Rats Rats, Wistar
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