Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis

Plaque rupture in atherosclerotic disease is the major cause of morbidity and correlates well with myeloperoxidase (MPO) secretion by activated neutrophils and macrophages in humans. We hypothesized that paramagnetic electron donor compounds that rapidly oxidize and polymerize in the presence of MPO...

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Veröffentlicht in:	Magnetic resonance in medicine 2004-11, Vol.52 (5), p.1021-1028
Hauptverfasser:	Chen, John W., Pham, Wellington, Weissleder, Ralph, Bogdanov Jr, Alexei
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis - enzymology atherosclerosis Contrast Media - chemical synthesis Heterocyclic Compounds - chemical synthesis Humans inflammation magnetic resonance imaging Magnetic Resonance Imaging - methods Molecular Structure Organometallic Compounds - chemical synthesis Peroxidase - metabolism Phantoms, Imaging
Online-Zugang:	Volltext
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