Synaptobrevin is essential for fast synaptic-vesicle endocytosis

Synaptobrevin-2 (VAMP-2), the major SNARE protein of synaptic vesicles, is required for fast calcium-triggered synaptic-vesicle exocytosis. Here we show that synaptobrevin-2 is also essential for fast synaptic-vesicle endocytosis. We demonstrate that after depletion of the readily releasable vesicle...

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Veröffentlicht in:	Nature cell biology 2004-11, Vol.6 (11), p.1102-1108
Hauptverfasser:	Deák, Ferenc, Schoch, Susanne, Liu, Xinran, Südhof, Thomas C., Kavalali, Ege T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Calcium Cancer Research Cell Biology Developmental Biology Endocytosis Endocytosis - physiology Horseradish Peroxidase - metabolism In Vitro Techniques letter Life Sciences Membrane proteins Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Knockout Microscopy, Electron Physiological aspects Pyridinium Compounds - metabolism Quaternary Ammonium Compounds - metabolism R-SNARE Proteins Stem Cells Synapses Synaptic Vesicles - metabolism Synaptic Vesicles - physiology
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