Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

We studied the effects of Lyn ablation on the survival of drug-resistant chronic myelogenous leukemia (CML) blast crisis cells using siRNA. Lyn siRNA reduced Lyn protein in both normal hematopoietic cells and BCR-ABL1-expressing (BCR-ABL1(+)) blasts by 80–95%. Within 48 h, siRNA-treated BCR-ABL1(+)...

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Veröffentlicht in:	Nature medicine 2004-11, Vol.10 (11), p.1187-1189
Hauptverfasser:	Ptasznik, Andrzej, Nakata, Yuji, Kalota, Anna, Emerson, Stephen G, Gewirtz, Alan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Apoptosis Apoptosis - physiology Biomedical and Life Sciences Biomedicine Blast Crisis - metabolism Blotting, Western brief-communication Cancer Research Crises Drug resistance Fusion Proteins, bcr-abl - metabolism Humans In Situ Nick-End Labeling Infectious Diseases Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Metabolic Diseases Molecular Medicine Neurosciences Proteins RNA Interference RNA, Small Interfering - metabolism RNA, Small Interfering - physiology Signal Transduction - physiology src-Family Kinases - metabolism Survival Tetrazolium Salts Thiazoles Tumor Cells, Cultured
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