Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case
A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm 3 , and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels wer...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2009-03, Vol.39 (3), p.241-246 |
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| container_title | Surgery today (Tokyo, Japan) |
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| creator | Shimada, Kazunori Iwase, Kazuhiro Aono, Toyokazu Nakai, Sumio Takeda, Shin-Ichi Fujii, Makoto Koma, Masaru Nishikawa, Kazuhiro Matsuda, Chu Hirota, Masashi Fushimi, Hiroaki Tanaka, Yasuhiro |
| description | A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm
3
, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative for G-CSF. This is the first report of a carcinosarcoma of the gallbladder producing AFP. The laboratory findings and clinical course strongly suggested that the tumor produced not only AFP, but also G-CSF. |
| doi_str_mv | 10.1007/s00595-008-3833-4 |
| format | Article |
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, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative for G-CSF. This is the first report of a carcinosarcoma of the gallbladder producing AFP. The laboratory findings and clinical course strongly suggested that the tumor produced not only AFP, but also G-CSF.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-008-3833-4</identifier><identifier>PMID: 19280285</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Aged ; alpha-Fetoproteins - metabolism ; Carcinosarcoma - diagnosis ; Carcinosarcoma - metabolism ; Carcinosarcoma - pathology ; Carcinosarcoma - surgery ; Case Report ; Cholangiopancreatography, Endoscopic Retrograde ; Cholecystectomy ; Gallbladder Neoplasms - diagnosis ; Gallbladder Neoplasms - metabolism ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - surgery ; Granulocyte Colony-Stimulating Factor - blood ; Humans ; Leukocytosis - pathology ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Surgery ; Surgical Oncology ; Tomography, X-Ray Computed</subject><ispartof>Surgery today (Tokyo, Japan), 2009-03, Vol.39 (3), p.241-246</ispartof><rights>Springer 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-778dc9cdca155fd7a4c2a6ac88f709207263cdd42eaa5e2533e4cb5f2f1461543</citedby><cites>FETCH-LOGICAL-c395t-778dc9cdca155fd7a4c2a6ac88f709207263cdd42eaa5e2533e4cb5f2f1461543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-008-3833-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-008-3833-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19280285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimada, Kazunori</creatorcontrib><creatorcontrib>Iwase, Kazuhiro</creatorcontrib><creatorcontrib>Aono, Toyokazu</creatorcontrib><creatorcontrib>Nakai, Sumio</creatorcontrib><creatorcontrib>Takeda, Shin-Ichi</creatorcontrib><creatorcontrib>Fujii, Makoto</creatorcontrib><creatorcontrib>Koma, Masaru</creatorcontrib><creatorcontrib>Nishikawa, Kazuhiro</creatorcontrib><creatorcontrib>Matsuda, Chu</creatorcontrib><creatorcontrib>Hirota, Masashi</creatorcontrib><creatorcontrib>Fushimi, Hiroaki</creatorcontrib><creatorcontrib>Tanaka, Yasuhiro</creatorcontrib><title>Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm
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, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative for G-CSF. This is the first report of a carcinosarcoma of the gallbladder producing AFP. The laboratory findings and clinical course strongly suggested that the tumor produced not only AFP, but also G-CSF.</description><subject>Aged</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Carcinosarcoma - diagnosis</subject><subject>Carcinosarcoma - metabolism</subject><subject>Carcinosarcoma - pathology</subject><subject>Carcinosarcoma - surgery</subject><subject>Case Report</subject><subject>Cholangiopancreatography, Endoscopic Retrograde</subject><subject>Cholecystectomy</subject><subject>Gallbladder Neoplasms - diagnosis</subject><subject>Gallbladder Neoplasms - metabolism</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - surgery</subject><subject>Granulocyte Colony-Stimulating Factor - blood</subject><subject>Humans</subject><subject>Leukocytosis - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuKFDEUhoMoTjv6AG4kK3fRXCpdKXfSeIMBQXQdTicnPTWmKm2SUvqF3PsiPpMpu8GdqwM53_nJz0fIU8FfCM77l4VzPWjGuWHKKMW6e2QjOrVl0gh1n2z40Akm5CCuyKNS7jiXneH8IbkSgzRcGr0hP3eQ3Tin0kaagKZA6y3SA8S4j-A9ZnrMyS-NOdDfv1jAmtpDxXGmMHs6wTwGLHVdQ6ERl6_JnWoqY6E_xnpLMeJ3qOhpwbxM9JBhXuKKIHUppvnE2vG0RPgbEcDVlF_RT3hMua6_Aeqg4GPyIEAs-OQyr8mXt28-796zm4_vPuxe3zCnBl1Z3xvvBucdCK2D76FzErbgjAk9HyTv5VY57zuJABqlVgo7t9dBBtFthe7UNXl-zm0dvy2tl53G4jBGmDEtxW57LrkZZAPFGXQ5lZIx2GMeJ8gnK7hd5dizHNvk2FWOXcOfXcKX_YT-38XFRgPkGShtNR8w27u05LkV_k_qHxQKoAc</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Shimada, Kazunori</creator><creator>Iwase, Kazuhiro</creator><creator>Aono, Toyokazu</creator><creator>Nakai, Sumio</creator><creator>Takeda, Shin-Ichi</creator><creator>Fujii, Makoto</creator><creator>Koma, Masaru</creator><creator>Nishikawa, Kazuhiro</creator><creator>Matsuda, Chu</creator><creator>Hirota, Masashi</creator><creator>Fushimi, Hiroaki</creator><creator>Tanaka, Yasuhiro</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case</title><author>Shimada, Kazunori ; Iwase, Kazuhiro ; Aono, Toyokazu ; Nakai, Sumio ; Takeda, Shin-Ichi ; Fujii, Makoto ; Koma, Masaru ; Nishikawa, Kazuhiro ; Matsuda, Chu ; Hirota, Masashi ; Fushimi, Hiroaki ; Tanaka, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-778dc9cdca155fd7a4c2a6ac88f709207263cdd42eaa5e2533e4cb5f2f1461543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Carcinosarcoma - diagnosis</topic><topic>Carcinosarcoma - metabolism</topic><topic>Carcinosarcoma - pathology</topic><topic>Carcinosarcoma - surgery</topic><topic>Case Report</topic><topic>Cholangiopancreatography, Endoscopic Retrograde</topic><topic>Cholecystectomy</topic><topic>Gallbladder Neoplasms - diagnosis</topic><topic>Gallbladder Neoplasms - metabolism</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - surgery</topic><topic>Granulocyte Colony-Stimulating Factor - blood</topic><topic>Humans</topic><topic>Leukocytosis - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimada, Kazunori</creatorcontrib><creatorcontrib>Iwase, Kazuhiro</creatorcontrib><creatorcontrib>Aono, Toyokazu</creatorcontrib><creatorcontrib>Nakai, Sumio</creatorcontrib><creatorcontrib>Takeda, Shin-Ichi</creatorcontrib><creatorcontrib>Fujii, Makoto</creatorcontrib><creatorcontrib>Koma, Masaru</creatorcontrib><creatorcontrib>Nishikawa, Kazuhiro</creatorcontrib><creatorcontrib>Matsuda, Chu</creatorcontrib><creatorcontrib>Hirota, Masashi</creatorcontrib><creatorcontrib>Fushimi, Hiroaki</creatorcontrib><creatorcontrib>Tanaka, Yasuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimada, Kazunori</au><au>Iwase, Kazuhiro</au><au>Aono, Toyokazu</au><au>Nakai, Sumio</au><au>Takeda, Shin-Ichi</au><au>Fujii, Makoto</au><au>Koma, Masaru</au><au>Nishikawa, Kazuhiro</au><au>Matsuda, Chu</au><au>Hirota, Masashi</au><au>Fushimi, Hiroaki</au><au>Tanaka, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>39</volume><issue>3</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm
3
, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative for G-CSF. This is the first report of a carcinosarcoma of the gallbladder producing AFP. The laboratory findings and clinical course strongly suggested that the tumor produced not only AFP, but also G-CSF.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>19280285</pmid><doi>10.1007/s00595-008-3833-4</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2009-03, Vol.39 (3), p.241-246 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67020892 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged alpha-Fetoproteins - metabolism Carcinosarcoma - diagnosis Carcinosarcoma - metabolism Carcinosarcoma - pathology Carcinosarcoma - surgery Case Report Cholangiopancreatography, Endoscopic Retrograde Cholecystectomy Gallbladder Neoplasms - diagnosis Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - pathology Gallbladder Neoplasms - surgery Granulocyte Colony-Stimulating Factor - blood Humans Leukocytosis - pathology Magnetic Resonance Imaging Male Medicine Medicine & Public Health Surgery Surgical Oncology Tomography, X-Ray Computed |
| title | Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case |
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