Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations
The purpose of this study was to determine the clinical significance of first trimester crown-rump disparity in dichorionic twin gestations. Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Med...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2004-10, Vol.191 (4), p.1437-1440 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Kalish, Robin B. Gupta, Meruka Perni, Sriram C. Berman, Seth Chasen, Stephen T. |
| description | The purpose of this study was to determine the clinical significance of first trimester crown-rump disparity in dichorionic twin gestations.
Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Medical records were reviewed for antenatal complications that included spontaneous abortion, fetal death, fetal structural or chromosomal anomalies, and preterm delivery. Fisher's exact test was used for statistical analysis; a probability value of 10%, which is the 90th percentile for intertwin crown-rump length disparity in our population, was associated with a significantly higher incidence of fetal anomalies (22.2% vs 2.8%; P=.01).
First trimester crown-rump length disparity in dichorionic twin gestations is associated with an increased risk of fetal structural and chromosomal anomalies. |
| doi_str_mv | 10.1016/j.ajog.2004.06.101 |
| format | Article |
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Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Medical records were reviewed for antenatal complications that included spontaneous abortion, fetal death, fetal structural or chromosomal anomalies, and preterm delivery. Fisher's exact test was used for statistical analysis; a probability value of <.05 was considered significant.
Of 159 twin pregnancies, there were 7 fetal structural anomalies, 2 fetal chromosomal anomalies, 5 second-trimester spontaneous abortions, 3 second-trimester fetal deaths, and 1 third-trimester fetal death. Pregnancies that were complicated by fetal structural or chromosomal anomalies had significantly greater median crown-rump length discordance than pregnancies without fetal anomalies (4.0 mm vs 2.0 mm; P=.02). Crown-rump length discordance >10%, which is the 90th percentile for intertwin crown-rump length disparity in our population, was associated with a significantly higher incidence of fetal anomalies (22.2% vs 2.8%; P=.01).
First trimester crown-rump length disparity in dichorionic twin gestations is associated with an increased risk of fetal structural and chromosomal anomalies.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2004.06.101</identifier><identifier>PMID: 15507979</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Abortion, Spontaneous - epidemiology ; Anomaly ; Biological and medical sciences ; Congenital Abnormalities - epidemiology ; Crown-Rump Length ; Discordance ; Female ; Fetal Death - epidemiology ; Fetal Development ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Nuchal Translucency Measurement ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy, Multiple ; Reproductive Techniques, Assisted ; ROC Curve ; Twin gestation ; Twins ; Ultrasonography, Prenatal</subject><ispartof>American journal of obstetrics and gynecology, 2004-10, Vol.191 (4), p.1437-1440</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-1512147498e96202444743a3e704d1e835a622f1a9e21eb5b85d230312d943e83</citedby><cites>FETCH-LOGICAL-c382t-1512147498e96202444743a3e704d1e835a622f1a9e21eb5b85d230312d943e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937804007240$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16242501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15507979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalish, Robin B.</creatorcontrib><creatorcontrib>Gupta, Meruka</creatorcontrib><creatorcontrib>Perni, Sriram C.</creatorcontrib><creatorcontrib>Berman, Seth</creatorcontrib><creatorcontrib>Chasen, Stephen T.</creatorcontrib><title>Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The purpose of this study was to determine the clinical significance of first trimester crown-rump disparity in dichorionic twin gestations.
Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Medical records were reviewed for antenatal complications that included spontaneous abortion, fetal death, fetal structural or chromosomal anomalies, and preterm delivery. Fisher's exact test was used for statistical analysis; a probability value of <.05 was considered significant.
Of 159 twin pregnancies, there were 7 fetal structural anomalies, 2 fetal chromosomal anomalies, 5 second-trimester spontaneous abortions, 3 second-trimester fetal deaths, and 1 third-trimester fetal death. Pregnancies that were complicated by fetal structural or chromosomal anomalies had significantly greater median crown-rump length discordance than pregnancies without fetal anomalies (4.0 mm vs 2.0 mm; P=.02). Crown-rump length discordance >10%, which is the 90th percentile for intertwin crown-rump length disparity in our population, was associated with a significantly higher incidence of fetal anomalies (22.2% vs 2.8%; P=.01).
First trimester crown-rump length disparity in dichorionic twin gestations is associated with an increased risk of fetal structural and chromosomal anomalies.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Anomaly</subject><subject>Biological and medical sciences</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Crown-Rump Length</subject><subject>Discordance</subject><subject>Female</subject><subject>Fetal Death - epidemiology</subject><subject>Fetal Development</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nuchal Translucency Measurement</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy, Multiple</subject><subject>Reproductive Techniques, Assisted</subject><subject>ROC Curve</subject><subject>Twin gestation</subject><subject>Twins</subject><subject>Ultrasonography, Prenatal</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9v2zAQxYkiReOk_QIdAi7tJuf4R5QIdCmMNAkQIEs7EzR1cmjIkkPSDfLte6oNZMtE3uO7d7wfY18FLAUIc71d-u20WUoAvQQzax_YQoBtKtOa9owtAEBWVjXtObvIeTuX0spP7FzUNTS2sQsWVkMcY_ADz3Ezxp6uY0A-9byPKRdeUtxhLph4SNPLWKXDbs8HHDfliXcx732K5ZXHkYrwNKU4URgvLyRsqM0XEvJn9rH3Q8Yvp_OS_fl183t1Vz083t6vfj5UQbWyVKIWUuhG2xatkSC1pkJ5hQ3oTmCram-k7IW3KAWu63Vbd1KBErKzWtH7Jft-zN2n6flA490u5oDD4EecDtmZBiQYpckoj0baKeeEvdvTmj69OgFuRuu2bkbrZrQOzKxR09Up_bDeYffWcmJJhm8ng88EtE9EMuY3n5Fa1v-Dfhx9SCz-Rkwuh4hEvYsJQ3HdFN_7xz_GupdM</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Kalish, Robin B.</creator><creator>Gupta, Meruka</creator><creator>Perni, Sriram C.</creator><creator>Berman, Seth</creator><creator>Chasen, Stephen T.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations</title><author>Kalish, Robin B. ; Gupta, Meruka ; Perni, Sriram C. ; Berman, Seth ; Chasen, Stephen T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-1512147498e96202444743a3e704d1e835a622f1a9e21eb5b85d230312d943e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Anomaly</topic><topic>Biological and medical sciences</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Crown-Rump Length</topic><topic>Discordance</topic><topic>Female</topic><topic>Fetal Death - epidemiology</topic><topic>Fetal Development</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nuchal Translucency Measurement</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy, Multiple</topic><topic>Reproductive Techniques, Assisted</topic><topic>ROC Curve</topic><topic>Twin gestation</topic><topic>Twins</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalish, Robin B.</creatorcontrib><creatorcontrib>Gupta, Meruka</creatorcontrib><creatorcontrib>Perni, Sriram C.</creatorcontrib><creatorcontrib>Berman, Seth</creatorcontrib><creatorcontrib>Chasen, Stephen T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalish, Robin B.</au><au>Gupta, Meruka</au><au>Perni, Sriram C.</au><au>Berman, Seth</au><au>Chasen, Stephen T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>191</volume><issue>4</issue><spage>1437</spage><epage>1440</epage><pages>1437-1440</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>The purpose of this study was to determine the clinical significance of first trimester crown-rump disparity in dichorionic twin gestations.
Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Medical records were reviewed for antenatal complications that included spontaneous abortion, fetal death, fetal structural or chromosomal anomalies, and preterm delivery. Fisher's exact test was used for statistical analysis; a probability value of <.05 was considered significant.
Of 159 twin pregnancies, there were 7 fetal structural anomalies, 2 fetal chromosomal anomalies, 5 second-trimester spontaneous abortions, 3 second-trimester fetal deaths, and 1 third-trimester fetal death. Pregnancies that were complicated by fetal structural or chromosomal anomalies had significantly greater median crown-rump length discordance than pregnancies without fetal anomalies (4.0 mm vs 2.0 mm; P=.02). Crown-rump length discordance >10%, which is the 90th percentile for intertwin crown-rump length disparity in our population, was associated with a significantly higher incidence of fetal anomalies (22.2% vs 2.8%; P=.01).
First trimester crown-rump length disparity in dichorionic twin gestations is associated with an increased risk of fetal structural and chromosomal anomalies.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>15507979</pmid><doi>10.1016/j.ajog.2004.06.101</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2004-10, Vol.191 (4), p.1437-1440 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abortion, Spontaneous - epidemiology Anomaly Biological and medical sciences Congenital Abnormalities - epidemiology Crown-Rump Length Discordance Female Fetal Death - epidemiology Fetal Development Gynecology. Andrology. Obstetrics Humans Medical sciences Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy, Multiple Reproductive Techniques, Assisted ROC Curve Twin gestation Twins Ultrasonography, Prenatal |
| title | Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations |
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