Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction
The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies. This was a case control study of IUGR pregnancies (birth weight
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2004-10, Vol.191 (4), p.1465-1469 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 191 |
| creator | Ilagan, John G. Stamilio, David M. Ural, Serdar H. Macones, George A. Odibo, Anthony O. |
| description | The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies.
This was a case control study of IUGR pregnancies (birth weight |
| doi_str_mv | 10.1016/j.ajog.2004.05.065 |
| format | Article |
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This was a case control study of IUGR pregnancies (birth weight <10th percentile for gestational age [GA]) delivered in our unit over 6 years. Cases were compared with controls for the association between abnormal MMS and adverse perinatal outcomes (APO).
Of the 261 IUGR pregnancies, 39 (16%) had at least 1 APO. An elevated HCG was significantly associated with an APO (OR 2.6, 95% CI 1.1–6.4). A low uE3 was also associated with an APO (OR 5.5, 95% CI 2.2–14). The association between an elevated AFP and APO was not statistically significant (OR 1.6, 95% CI, 0.6–4.6).
An elevated HCG and low uE3 were associated with APO in cases of IUGR. This information could be useful in identifying a subset of IUGR cases deserving closer surveillance.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2004.05.065</identifier><identifier>PMID: 15507984</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Abnormal multiple markers ; alpha-Fetoproteins - analysis ; Biological and medical sciences ; Case-Control Studies ; Diseases of mother, fetus and pregnancy ; Estriol - blood ; Female ; Fetal Growth Retardation - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Intrauterine growth restriction ; Logistic Models ; Medical sciences ; Perinatal outcomes ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; ROC Curve ; Sensitivity and Specificity</subject><ispartof>American journal of obstetrics and gynecology, 2004-10, Vol.191 (4), p.1465-1469</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-19b69b5d24769aeee526105703100961783a8a87612bf43f333c64fd359a42a03</citedby><cites>FETCH-LOGICAL-c382t-19b69b5d24769aeee526105703100961783a8a87612bf43f333c64fd359a42a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2004.05.065$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16242506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15507984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilagan, John G.</creatorcontrib><creatorcontrib>Stamilio, David M.</creatorcontrib><creatorcontrib>Ural, Serdar H.</creatorcontrib><creatorcontrib>Macones, George A.</creatorcontrib><creatorcontrib>Odibo, Anthony O.</creatorcontrib><title>Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies.
This was a case control study of IUGR pregnancies (birth weight <10th percentile for gestational age [GA]) delivered in our unit over 6 years. Cases were compared with controls for the association between abnormal MMS and adverse perinatal outcomes (APO).
Of the 261 IUGR pregnancies, 39 (16%) had at least 1 APO. An elevated HCG was significantly associated with an APO (OR 2.6, 95% CI 1.1–6.4). A low uE3 was also associated with an APO (OR 5.5, 95% CI 2.2–14). The association between an elevated AFP and APO was not statistically significant (OR 1.6, 95% CI, 0.6–4.6).
An elevated HCG and low uE3 were associated with APO in cases of IUGR. This information could be useful in identifying a subset of IUGR cases deserving closer surveillance.</description><subject>Abnormal multiple markers</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Estriol - blood</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intrauterine growth restriction</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Perinatal outcomes</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCC3BAvsBtw9iOnUTiUlVAkSpxgbM1cSbFSxIvttMK8fI42pV64zQz0vfPjD7G3gioBAjz4VDhIdxXEqCuQFdg9DO2E9A1e9Oa9jnbAYDcd6ppL9hlSodtlJ18yS6E1tB0bb1jf6_7JcQZJz6vU_bHifiM8RdFnlwkWhLHSBxTCs5jpoE_-vyT4_BAMRE_UvQL5pIOa3ZhpsT9wh2m0oSx9DnimjeI-H0MjyUaKeXoXfZhecVejDglen2uV-zH50_fb273d9--fL25vts71cq8F11vul4Psm5Mh0SkpRGgG1ACoDOiaRW22DZGyH6s1aiUcqYeB6U7rCWCumLvT3uPMfxey307--RomnChsCZrGhCtEKaA8gS6GFKKNNpj9EXHHyvAbsrtwW7K7abcgrZFeQm9PW9f-5mGp8jZcQHenQFMDqcx4uJ8euKMrKWG7frHE0fFxYOnaJPztDgafCSX7RD8__74B8w0oQw</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Ilagan, John G.</creator><creator>Stamilio, David M.</creator><creator>Ural, Serdar H.</creator><creator>Macones, George A.</creator><creator>Odibo, Anthony O.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction</title><author>Ilagan, John G. ; Stamilio, David M. ; Ural, Serdar H. ; Macones, George A. ; Odibo, Anthony O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-19b69b5d24769aeee526105703100961783a8a87612bf43f333c64fd359a42a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abnormal multiple markers</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Estriol - blood</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intrauterine growth restriction</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Perinatal outcomes</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilagan, John G.</creatorcontrib><creatorcontrib>Stamilio, David M.</creatorcontrib><creatorcontrib>Ural, Serdar H.</creatorcontrib><creatorcontrib>Macones, George A.</creatorcontrib><creatorcontrib>Odibo, Anthony O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilagan, John G.</au><au>Stamilio, David M.</au><au>Ural, Serdar H.</au><au>Macones, George A.</au><au>Odibo, Anthony O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>191</volume><issue>4</issue><spage>1465</spage><epage>1469</epage><pages>1465-1469</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies.
This was a case control study of IUGR pregnancies (birth weight <10th percentile for gestational age [GA]) delivered in our unit over 6 years. Cases were compared with controls for the association between abnormal MMS and adverse perinatal outcomes (APO).
Of the 261 IUGR pregnancies, 39 (16%) had at least 1 APO. An elevated HCG was significantly associated with an APO (OR 2.6, 95% CI 1.1–6.4). A low uE3 was also associated with an APO (OR 5.5, 95% CI 2.2–14). The association between an elevated AFP and APO was not statistically significant (OR 1.6, 95% CI, 0.6–4.6).
An elevated HCG and low uE3 were associated with APO in cases of IUGR. This information could be useful in identifying a subset of IUGR cases deserving closer surveillance.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>15507984</pmid><doi>10.1016/j.ajog.2004.05.065</doi><tpages>5</tpages></addata></record> |
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| issn | 0002-9378 1097-6868 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abnormal multiple markers alpha-Fetoproteins - analysis Biological and medical sciences Case-Control Studies Diseases of mother, fetus and pregnancy Estriol - blood Female Fetal Growth Retardation - blood Gynecology. Andrology. Obstetrics Humans Intrauterine growth restriction Logistic Models Medical sciences Perinatal outcomes Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta ROC Curve Sensitivity and Specificity |
| title | Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction |
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