Epstein-Barr virus: 40 years on

Key Points Epstein–Barr virus (EBV) infection is implicated in the aetiology of several different lymphoid and epithelial malignancies. EBV-encoded latent genes induce B-cell transformation in vitro by altering cellular gene transcription and constitutively activating key cell-signalling pathways. E...

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Veröffentlicht in:	Nature reviews. Cancer 2004-10, Vol.4 (10), p.757-768
Hauptverfasser:	Young, Lawrence S, Rickinson, Alan B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral - genetics Antigens, Viral - physiology B-Lymphocytes - pathology B-Lymphocytes - virology Biomedical and Life Sciences Biomedicine Burkitt Lymphoma - epidemiology Burkitt Lymphoma - virology Cancer Research Carcinoma - therapy Carcinoma - virology Cell Transformation, Neoplastic Cell Transformation, Viral Epstein-Barr virus Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Infections - virology Herpesvirus 4, Human - genetics Herpesvirus 4, Human - pathogenicity Herpesvirus 4, Human - physiology Humans Immunocompromised Host Killer Cells, Natural - pathology Lymphoma - therapy Lymphoma - virology Lymphoma, B-Cell - immunology Lymphoma, B-Cell - virology Lymphoma, T-Cell - virology Nasopharyngeal Neoplasms - epidemiology Nasopharyngeal Neoplasms - virology review-article Stomach Neoplasms - virology Viral Proteins - genetics Viral Proteins - physiology Virus Latency
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